The Drosophila nucleoporin gene nup154 is required for correct microfilament dynamics and cell death during oogenesis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• The Drosophila nucleoporin gene nup154 is required for correct microfilament dynamics and cell death during oogenesis (Articolo in rivista) (literal)

Anno

• 2007-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/cm.20206 (literal)

Alternative label

• Riparbelli M.G.; Gigliotti S.; Callaini G. (2007)
  The Drosophila nucleoporin gene nup154 is required for correct microfilament dynamics and cell death during oogenesis
  in Cell motility and the cytoskeleton (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Riparbelli M.G.; Gigliotti S.; Callaini G. (literal)

Pagina inizio

• 590 (literal)

Pagina fine

• 604 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 64 (literal)

Rivista

• Cell motility and the cytoskeleton (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto

• Pubblicazione (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Evolutionary Biology, University of Siena, I-53100 Siena, Italy Institute of Genetics and Biophysics, Adriano Buzzati Traverso, CNR, Naples, Italy (literal)

Titolo

• The Drosophila nucleoporin gene nup154 is required for correct microfilament dynamics and cell death during oogenesis (literal)

Abstract

• The Drosophila nucleoporin gene nup154 is required in both male and female germline for successful gametogenesis. Mutant flies lack differentiated sperm and lay abnormal eggs. We demonstrated that the egg phenotype was associated with specific alterations of the actin cytoskeleton at different stages of oogenesis. Actually, mutant egg chambers displayed an abnormal organization of both subcortical microfilaments and cytoplasmic actin bundles, that led to defective nurse cell dumping. TUNEL analysis also showed that the dumpless phenotype was associated with delayed apoptosis. The nup154 gene product was localized by conventional immunofluorescence microscopy to the nuclear envelope in a distinct punctuate pattern, characteristic of nuclear pore complex components. TEM analysis revealed that the protein was mainly distributed along filamentous structures that extended radially on the nuclear side of the pore, suggesting that Nup154 could be an integral component of the basket filaments associated with the nuclear pore complexes. We propose that Nup154 is necessary for correct nuclear pore complex functions and that the proper regulation of the actin cytoskeleton dynamics strongly relies upon nuclear pore integrity. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)
• Le interazioni benefiche fra organismi: dalla lotta biologica alla messa a punto di strumenti per un'agricoltura sostenibile. (AG.P01.005.001) (Modulo)

Autore CNR

• SILVIA GIGLIOTTI (Persona)

Insieme di parole chiave

• Keywords of "The Drosophila nucleoporin gene nup154 is required for correct microfilament dynamics and cell death during oogenesis" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)
• Le interazioni benefiche fra organismi: dalla lotta biologica alla messa a punto di strumenti per un'agricoltura sostenibile. (AG.P01.005.001) (Modulo)

Autore CNR di

• SILVIA GIGLIOTTI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cell motility and the cytoskeleton (Rivista)

Insieme di parole chiave di

• Keywords of "The Drosophila nucleoporin gene nup154 is required for correct microfilament dynamics and cell death during oogenesis" (Insieme di parole chiave)