A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1242/dev.02181 (literal)

Alternative label

• Prakash N.; Brodski C.; Naserke T.; Puelles E.; Gogoi R.; Hall A.; Panhuysen M.; Echevarria D.; Sussel L.; Weisenhorn D.M.; Martinez S.; Arenas E.; Simeone A.; Wurst W. (2006)
  A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo
  in Development (Camb.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Prakash N.; Brodski C.; Naserke T.; Puelles E.; Gogoi R.; Hall A.; Panhuysen M.; Echevarria D.; Sussel L.; Weisenhorn D.M.; Martinez S.; Arenas E.; Simeone A.; Wurst W. (literal)

Pagina inizio

• 89 (literal)

Pagina fine

• 98 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 133 (literal)

Rivista

• Development (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• GSF-National Research Center for Environment and Health, Technical University Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, 85764 Munich/Neuherberg, Germany, and Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany. Ben-Gurion University of the Negev, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Department of Morphology, Be'er Sheva 84105, Israel. MRC Centre for Developmental Neurobiology, 4th floor, New Hunt's House, King's College London, Guy's Campus, London Bridge, London SE1 UL, UK. Laboratory of Molecular Neurobiology, MBB, Karolinska Institute, 17177 Stockholm, Sweden. Instituto de Neurociencias, Universidad Miguel Hernandez, San Juan, 03550 Alicante, Spain. Barbara Davis Center, University of Colorado Health Science Center, 4200 E. 9th Avenue, Denver, CO 8020, USA. CEINGE Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Naples, Italy. Institute of Genetics and Biophysics `ABT', Via Guglielmo Marconi 12, 80125 Naples, Italy. (literal)

Titolo

• A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo (literal)

Abstract

• Midbrain neurons synthesizing the neurotransmitter dopamine play a central role in the modulation of different brain functions and are associated with major neurological and psychiatric disorders. Despite the importance of these cells, the molecular mechanisms controlling their development are still poorly understood. The secreted glycoprotein Wnt1 is expressed in close vicinity to developing midbrain dopaminergic neurons. Here, we show that Wnt1 regulates the genetic network, including Otx2 and Nkx2-2, that is required for the establishment of the midbrain dopaminergic progenitor domain during embryonic development. In addition, Wnt1 is required for the terminal differentiation of midbrain dopaminergic neurons at later stages of embryogenesis. These results identify Wnt1 as a key molecule in the development of midbrain dopaminergic neurons in vivo. They also suggest the Wnt1-controlled signaling pathway as a promising target for new therapeutic strategies in the treatment of Parkinson's disease. (literal)

Prodotto di

• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• ANTONIO SIMEONE (Persona)

Insieme di parole chiave

• Parole chiave di "A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR di

• ANTONIO SIMEONE (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Development (Rivista)

Insieme di parole chiave di

• Parole chiave di "A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo" (Insieme di parole chiave)