Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation (Articolo in rivista)

Type
Label
  • Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1523/JNEUROSCI.1097-06.2006 (literal)
Alternative label
  • Puelles E.; Acampora D.; Gogoi R.; Tuorto F.; Papalia A.; Guillemot F.; Ang S.L.; Simeone A. (2006)
    Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation
    in The Journal of neuroscience
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Puelles E.; Acampora D.; Gogoi R.; Tuorto F.; Papalia A.; Guillemot F.; Ang S.L.; Simeone A. (literal)
Pagina inizio
  • 5955 (literal)
Pagina fine
  • 5964 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 26 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 22 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Medical Research Council Centre for Developmental Neurobiology, King's College London, London SE1 1UL, United Kingdom, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy, Scuola Europea di Medicina Molecolare, 80145 Naples, Italy, Institute of Genetics and Biophysics \"A. Buzzati-Traverso,\" Consiglio Nazionale delle Ricerche, 80131 Naples, Italy, and Division of Developmental Neurobiology, National Institute for Medical Research, London NW7 1AA, United Kingdom (literal)
Titolo
  • Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation (literal)
Abstract
  • GABAergic and glutamatergic neurons modulate inhibitory and excitatory networks in the CNS, and their impairment may cause neurological and psychiatric disorders. Thus, understanding the molecular mechanisms that control neurotransmitter phenotype and identity of excitatory and inhibitory progenitors has considerable relevance. Here we investigated the consequence of Otx2 (orthodenticle homolog) ablation in glutamatergic progenitors of the dorsal thalamus (referred to as thalamus). We report that Otx2 is cell-autonomously required in these progenitors to repress GABAergic differentiation. Our data indicate that Otx2 may prevent GABAergic fate switch by repressing the basic helix–loop–helix gene Mash1 (mammalian achaete-schute homolog) in progenitors expressing Ngn2 (neurogenin homolog). The lack of Otx2 also resulted in the activation of Pax3 (paired box gene), Pax7, and Lim1 (Lin-11/Isl-1/Mec-3), three genes normally coexpressed with Mash1 and GABAergic markers in the pretectum, thus suggesting that thalamic progenitors lacking Otx2 exhibit marker similarities with those of the pretectum. Furthermore, Otx2 ablation gave rise to a marked increase in proliferating activity of thalamic progenitors and the formation of hyperplastic cell masses. Thus, this study provides evidence for a novel and crucial role of Otx2 in the molecular mechanism by which identity and fate of glutamatergic precursors are established in the thalamus. Our data also support the concept that proper assignment of identity and fate of neuronal precursors occurs through the suppression of alternative differentiation programs. (literal)
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