Visualizing pancreatic beta-cell mass with [11C]DTBZ (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Visualizing pancreatic beta-cell mass with [11C]DTBZ (Articolo in rivista) (literal)

Anno

• 2006-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.nucmedbio.2006.07.002 (literal)

Alternative label

• Simpson, N. ; Souza, F. ; Witkowski, P. ; Maffei, A. ; Raffo, A. ; Herron, A. ; Kilbourn, M. ; Jurewicz, A. ; Herold, K. ; Liu, E. ; Hardy, MA ; Van Heertum, R. ; Harris, PE (2006)
  Visualizing pancreatic beta-cell mass with [11C]DTBZ
  in Nuclear medicine and biology; Elsevier Science Inc., New York (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Simpson, N. ; Souza, F. ; Witkowski, P. ; Maffei, A. ; Raffo, A. ; Herron, A. ; Kilbourn, M. ; Jurewicz, A. ; Herold, K. ; Liu, E. ; Hardy, MA ; Van Heertum, R. ; Harris, PE (literal)

Pagina inizio

• 855 (literal)

Pagina fine

• 864 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• Nuclear medicine and biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Columbia Univ, Sch Med, Dept Radiol, New York, NY 10032 USA; Columbia Univ, Sch Med, Dept Med, New York, NY 10032 USA; Columbia Univ, Sch Med, Dept Surg, New York, NY 10032 USA; CNR, Inst Genet & Biophys Adriano Buzzati Traverso, I-80131 Naples, Italy; Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA; Baylor Coll Med, Ctr Comparat Med, Houston, TX 77030 USA; Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA; NIDDK, Diabet Branch, NIH, Bethesda, MD 20854 USA (literal)

Titolo

• Visualizing pancreatic beta-cell mass with [11C]DTBZ (literal)

Abstract

• Beta-cell mass (BCM) influences the total amount of insulin secreted, varies by individual and by the degree of insulin resistance, and is affected by physiologic and pathologic conditions. The islets of Langerhans, however, appear to have a reserve capacity of insulin secretion and, overall, assessments of insulin and blood glucose levels remain poor measures of BCM, beta-cell function and progression of diabetes. Thus, novel noninvasive determinations of BCM are needed to provide a quantitative endpoint for novel therapies of diabetes, islet regeneration and transplantation. Built on previous gene expression studies, we tested the hypothesis that the targeting of vesicular monoamine transporter 2 (VMAT2), which is expressed by beta cells, with [11C]dihydrotetrabenazine ([11C]DTBZ), a radioligand specific for VMAT2, and the use of positron emission tomography (PET) can provide a measure of BCM. In this report, we demonstrate decreased radioligand uptake within the pancreas of Lewis rats with streptozotocin-induced diabetes relative to their euglycemic historical controls. These studies suggest that quantitation of VMAT2 expression in beta cells with the use of [11C]DTBZ and PET represents a method for noninvasive longitudinal estimates of changes in BCM that may be useful in the study and treatment of diabetes. (literal)

Editore

• Elsevier Science Inc. (Editore)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)

Autore CNR

• ANTONELLA MAFFEI (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Analisi cellulare e molecolare della risposta immunitaria indotta da vaccini sintetici (SV.P15.009.002) (Modulo)

Autore CNR di

• ANTONELLA MAFFEI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nuclear medicine and biology (Rivista)

Editore di

• Elsevier Science Inc. (Editore)