The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis (Articolo in rivista)

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  • The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1096/fj.05-4147com (literal)
Alternative label
  • Tarsitano M, De Falco S, Colonna V, McGhee JD, Persico MG. (2006)
    The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis
    in The FASEB journal; Federation Of American Societies Of Experimental Biology, Bethesda (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tarsitano M, De Falco S, Colonna V, McGhee JD, Persico MG. (literal)
Pagina inizio
  • 227 (literal)
Pagina fine
  • 233 (literal)
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  • http://www.fasebj.org/content/20/2/227.long (literal)
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  • 20 (literal)
Rivista
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  • 2 (literal)
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  • ISI Web of Science (WOS) (literal)
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  • Institute of Genetics and Biophysics \"A. Buzzati-Traverso\", CNR, Naples, Italy. Department of Biochemistry and Molecular Biology, Genes and Development Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1 (literal)
Titolo
  • The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis (literal)
Abstract
  • Members of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family have been implicated in a variety of functions in vertebrates, especially angiogenesis. Here we identify and characterize a PDGF/VEGF-like factor (named PVF-1) from the nematode C. elegans. We show that PVF-1 has biochemical properties similar to vertebrate PDGF/VEGF growth factors. More important, PVF-1 binds to the human receptors VEGFR-1 (Flt-1) and VEGFR-2 (KDR) and is able to induce angiogenesis in two model systems derived from vertebrates. Our results highlight the widespread evolutionary conservation of this important class of growth factors and raise the possibility that C. elegans can provide a simple experimental system in which to investigate how these factors function.—Tarsitano, M., De Falco, S., Colonna, V., McGhee, J. D., Persico, M. G. The C. elegans pvf-1 gene encodes a PDGF/VEGF-like factor able to bind mammalian VEGF receptors and to induce angiogenesis. (literal)
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