Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice (Articolo in rivista)

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  • Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.mcn.2005.09.018 (literal)
Alternative label
  • Borgkvist A.; Puelles E.; Carta M.; Acampora D.; Ang S.L.; Wurst W.; Goiny M.; Fisone G.; Simeone A.; Usiello A. (2006)
    Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice
    in Molecular and cellular neurosciences (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Borgkvist A.; Puelles E.; Carta M.; Acampora D.; Ang S.L.; Wurst W.; Goiny M.; Fisone G.; Simeone A.; Usiello A. (literal)
Pagina inizio
  • 293 (literal)
Pagina fine
  • 302 (literal)
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  • 31 (literal)
Rivista
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  • 2 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • Department of Neuroscience, Karolinska Institutet, Retzius väg 8, S-17177 Stockholm, Sweden MRC Centre for Developmental Neurobiology, New Hunt's House, 4th Floor, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK Universita' di Cagliari Sezione di Fisiologia e Nutrizione Umana, Via Porcell 4, I-09124, Cagliari, Sardinia, Italy CEINGE-Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Naples, Italy Institute of Genetics and Biophysics “A. Buzzati-Traverso”, CNR, Via G. Marconi 12, 80125 Naples, Italy fDivision of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK GSF-Research Center, Institute of Developmental Genetics, 85764 Munich/Neuherberg, Max-Planck-Institute of Psychiatry, Molecular Neurogenetics, Kraepelinstr. 2-16, 80804 Munich, Germany Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden (literal)
Titolo
  • Altered dopaminergic innervation and amphetamine response in adult Otx2 conditional mutant mice (literal)
Abstract
  • Here, we have investigated the neurological consequences of restricted inactivation of Otx2 in adult En1cre/+; Otx2flox/flox mice. In agreement with the crucial role of Otx2 in midbrain patterning, the mutants had a substantial reduction in tyrosine hydroxylase containing neurons. Although the reduction in the number of DAergic neurons was comparable between the SNc and the VTA, we found an unexpected selectivity in the deinnervation of the terminal fields affecting preferentially the ventral striatum and the olfactory tubercle. Interestingly, the mutants showed no abnormalities in exploratory activity or motor coordination. However, the absence of normal DA tone generated significant alterations in DA D1-receptor signalling as indicated by increased mutant striatal levels of phosphorylated DARPP-32 and by an altered motor response to amphetamine. Therefore, we suggest that the En1cre/+; Otx2flox/flox mutant mouse model represents a genetic tool for investigating molecular and behavioural consequences of developmental neuronal dysfunction in the DAergic system. (literal)
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