Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD (Articolo in rivista) (literal)

Anno

• 2003-01-01T00:00:00+01:00 (literal)

Alternative label

• Leo D, Sorrentino E, Volpicelli F, Eyman M, Greco D, Viggiano D, di Porzio U, Perrone-Capano C (2003)
  Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD
  in Neuroscience and biobehavioral reviews
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Leo D, Sorrentino E, Volpicelli F, Eyman M, Greco D, Viggiano D, di Porzio U, Perrone-Capano C (literal)

Pagina inizio

• 661 (literal)

Pagina fine

• 663 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 27 (literal)

Rivista

• Neuroscience and biobehavioral reviews (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD (literal)

Abstract

• To understand the onset and the molecular mechanisms triggering dopaminergic (DA) dysregulation in Attention-Deficit Hyperactivity Disorder (ADHD), we have used the Spontaneously Hypertensive Rats (SHR), the most widely studied animal model for this disease. We have studied the pattern of expression of specific genes involved in DA neuron differentiation, survival and function during postnatal (P) development of the ventral midbrain in SHR males. Our results show that tyrosine hydroxylase and DA transporter gene expression are significantly and transiently reduced in the SHR midbrain during the first month of postnatal development, although with a different kinetic. The other genes analyzed do not show significant variation between SHR and control rats. In addition, high-affinity DA uptake activity is significantly reduced in synaptosomes obtained from the striatum of 1-month-old SHR, when compared to controls. Our data suggest that down-regulation of DA neurotransmission occurs in the midbrain of SHR in a developmentally regulated temporal window during postnatal development, thus strengthening the hypodopaminergic hypothesis in the pathogenesis of ADHD. (literal)

Prodotto di

• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)
• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)

Autore CNR

• UMBERTO DI PORZIO (Unità di personale interno)

Incoming links:

Prodotto

• Institute of genetics and biophysics \"Adriano Buzzati Traverso\" (IGB) (Istituto)
• Meccanismi molecolari e cellulari della determinazione neurale, differenziamento neuronale e patologie del sistema nervoso (SV.P16.006.001) (Modulo)
• Sviluppo e funzionamento dei sistemi complessi - Uso di modelli biologici (SV.P16.005.001) (Modulo)

Autore CNR di

• UMBERTO DI PORZIO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience and biobehavioral reviews (Rivista)