http://www.cnr.it/ontology/cnr/individuo/prodotto/ID26375
Cripto: a tumor growth factor and more (Articolo in rivista)
- Type
- Label
- Cripto: a tumor growth factor and more (Articolo in rivista) (literal)
- Anno
- 2002-01-01T00:00:00+01:00 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Adamson ED, Minchiotti G, Salomon DS (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Titolo
- Cripto: a tumor growth factor and more (literal)
- Abstract
- Cripto, a growth factor with an EGF-like domain, and the first member of the
EGF-CFC family of genes to be sequenced and characterized, contributes to
deregulated growth of cancer cells. A role for Cripto in tumor development
has been described in the human and the mouse. Members of the EGF-CFC family
are found only in vertebrates: CFC proteins in zebrafish, Xenopus, chick,
mouse and human have been characterized and indicate some common general
functions in development. Cripto expression was first found in human and
mouse embryonal carcinoma cells and male teratocarcinomas, and was
demonstrated to be over-expressed in breast, cervical, ovarian, gastric,
lung, colon, and pancreatic carcinomas in contrast to normal tissues where
Cripto expression was invariably low or absent. Cripto may play a role in
mammary tumorigenesis, since in vitro, Cripto induces mammary cell
proliferation, reduces apoptosis, increases cell migration, and inhibits
milk protein expression. This prediction is strengthened by observations of
Cripto expression in 80% of human and mouse mammary tumors. At least three
important roles for Cripto in development have created considerable
interest, and each activity may be distinct in its mechanism of receptor
signaling. One role is in the patterning of the anterior-posterior axis of
the early embryo, a second is a crucial role in the development of the
heart, and a third is in potentiating branching morphogenesis and modulating
differentiation in the developing mammary gland. Whether these properties
are functions of different forms of Cripto, different Cripto receptors or
the distinct domains within this 15-38 kDa glycoprotein are examined here,
but much remains to be revealed about this evolutionarily conserved gene
product. Since all Cripto receptors have not yet been determined with
certainty, future possible uses as therapeutic targets remain to be
developed. Cripto is released or shed from expressing cells and may serve as
an accessible marker gene in the early to mid-progressive stages of breast
and other cancers. Meanwhile some speculations on possible receptor
complexes for Cripto signaling in mammary cells are offered here as a spur
to further discoveries.
(literal)
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