Role of the EGF-CFC gene cripto in cell differentiation and embryo development (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Role of the EGF-CFC gene cripto in cell differentiation and embryo development (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• Minchiotti G, Parisi S, Liguori GL, D'Andrea D, Persico MG. (2002)
  Role of the EGF-CFC gene cripto in cell differentiation and embryo development
  in Gene (Amst.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Minchiotti G, Parisi S, Liguori GL, D'Andrea D, Persico MG. (literal)

Pagina inizio

• 33 (literal)

Pagina fine

• 37 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 287 (literal)

Rivista

• Gene (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Role of the EGF-CFC gene cripto in cell differentiation and embryo development (literal)

Abstract

• The EGF-CFC proteins have been recently recognized as a novel family of extracellular factors required during early vertebrate development. Cripto is the founder member of the EGF-CFC family initially related to the epidermal growth factor (EGF); its expression is increased in human colon, gastric, pancreatic and lung carcinoma and in different types of both mouse and human breast carcinomas. Genetic studies in the mouse have established an essential role of cripto in the formation and correct positioning of the anterior-posterior axis. Furthermore, the absence of cripto results in a defective precardiac mesoderm, unable to differentiate into functional cardiomyocytes. Although mouse and human Cripto have been shown to activate the ras/raf/MAP kinase pathway in mammary epithelial cell lines, genetic evidence in Zebrafish has been provided for a relationship between the EGF-CFC proteins and Nodal, a member of the transforming growth factor family. Here we review the biological role of cripto in development and differentiation, pointing out recent findings on the biochemical interactions of Cripto, Nodal and Activin-like receptors. (literal)

Prodotto di

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR

• GIOVANNA LUCIA LIGUORI (Unità di personale interno)
• GABRIELLA MINCHIOTTI (Persona)
• MARIA PERSICO (Persona)

Incoming links:

Prodotto

• Istituto di genetica e biofisica \"Adriano Buzzati Traverso\" (IGB) (Istituto)

Autore CNR di

• GIOVANNA LUCIA LIGUORI (Unità di personale interno)
• GABRIELLA MINCHIOTTI (Persona)
• MARIA PERSICO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Gene (Rivista)