In Vitro Pharmacological and Toxicological Effects of Norterpene Peroxides Isolated from the Red Sea Sponge Diacarnus erythraeanus on Normal and Cancer Cells. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• In Vitro Pharmacological and Toxicological Effects of Norterpene Peroxides Isolated from the Red Sea Sponge Diacarnus erythraeanus on Normal and Cancer Cells. (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/np400107t (literal)

Alternative label

• Florence Lefranc, Genoveffa Nuzzo, Nehal Aly Hamdy, Issa Fakhr, Laetitia Moreno Y Banuls, Gwendoline Van Goietsenoven, Guido Villani, Ve?ronique Mathieu, Rob van Soest, Robert Kiss, and Maria Letizia Ciavatta (2013)
  In Vitro Pharmacological and Toxicological Effects of Norterpene Peroxides Isolated from the Red Sea Sponge Diacarnus erythraeanus on Normal and Cancer Cells.
  in Journal of natural products (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Florence Lefranc, Genoveffa Nuzzo, Nehal Aly Hamdy, Issa Fakhr, Laetitia Moreno Y Banuls, Gwendoline Van Goietsenoven, Guido Villani, Ve?ronique Mathieu, Rob van Soest, Robert Kiss, and Maria Letizia Ciavatta (literal)

Pagina inizio

• 1541 (literal)

Pagina fine

• 1547 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 76 (literal)

Rivista

• Journal of natural products (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 9 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Service de Neurochirurgie, Ho?pital Erasme, ULB, Route de Lennik, 1070 Brussels, Belgium Istituto di Chimica Biomolecolare (ICB), Consiglio Nazionale delle Ricerche (CNR), Via Campi Flegrei 34, I-80078 Pozzuoli, Naples, Italy Department of Applied Organic Chemistry, National Research Center, Cairo 12613, Egypt Laboratoire de Toxicologie, Faculte? de Pharmacie, Universite? Libre de Bruxelles, Campus de la Plaine, CP205/1, Boulevard du Triomphe, 1050 Brussels, Belgium Department of Marine Zoology, Naturalis Biodiversity Center, P.O. Box 9517, 2300 RA Leiden, The Netherlands (literal)

Titolo

• In Vitro Pharmacological and Toxicological Effects of Norterpene Peroxides Isolated from the Red Sea Sponge Diacarnus erythraeanus on Normal and Cancer Cells. (literal)

Abstract

• Eight cyclic peroxide norterpenoids, compounds 1-8, have been isolated and characterized from the Red Sea sponge Diacarnus erythraeanus, including two new norsesterterpene derivatives (3, 4). Among these metabolites, (-)-muqubilin A (5) (nine cell lines analyzed) and the new compounds 3 and 4 (seven cell lines analyzed) displayed mean IC50 growth inhibitory concentrations in vitro of <10 ?M, while the remaining compounds (1, 6-8) were inactive in these cancer cell lines. Compound 5 displayed no selectivity between normal and cancer cells in terms of in vitro growth inhibition. Quantitative video microscopy analysis carried out on (-)-muqubilin A-treated cells validated the data obtained by means of the MTT colorimetric assay, while flow cytometry analysis revealed ROS production but no induction of apoptosis in cancer cells. (literal)

Prodotto di

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Esplorazione della diversità chimica in organismi marini in funzione del drug discovery (PM.P01.020.001) (Modulo)

Autore CNR

• GENOVEFFA NUZZO (Persona)
• MARIA LETIZIA CIAVATTA (Unità di personale interno)
• GUIDO VILLANI (Persona)

Insieme di parole chiave

• Keywords of "In Vitro Pharmacological and Toxicological Effects of Norterpene Peroxides Isolated from the Red Sea Sponge Diacarnus erythraeanus on Normal and Cancer Cells." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA LETIZIA CIAVATTA (Unità di personale interno)
• GUIDO VILLANI (Persona)
• GENOVEFFA NUZZO (Persona)

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Esplorazione della diversità chimica in organismi marini in funzione del drug discovery (PM.P01.020.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of natural products (Rivista)

Insieme di parole chiave di

• Keywords of "In Vitro Pharmacological and Toxicological Effects of Norterpene Peroxides Isolated from the Red Sea Sponge Diacarnus erythraeanus on Normal and Cancer Cells." (Insieme di parole chiave)