http://www.cnr.it/ontology/cnr/individuo/prodotto/ID260825

Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset (Articolo in rivista)

Type

Label

Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Di Rienzo C. [ 1,2,3 ] ; Jacchetti E. [ 1,2 ] ; Cardarelli F. [ 3 ] ; Bizzarri R. [ 1,2 ] ; Beltram F. [ 1,2 ] ; Cecchini M. [ 1,2 ] (2013)
Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset
in Scientific reports (Nature Publishing Group); Nature Publishing Group, London (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Di Rienzo C. [ 1,2,3 ] ; Jacchetti E. [ 1,2 ] ; Cardarelli F. [ 3 ] ; Bizzarri R. [ 1,2 ] ; Beltram F. [ 1,2 ] ; Cecchini M. [ 1,2 ] (literal)

Rivista

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

[ 1 ] CNR, Ist Nanosci, NEST, I-56127 Pisa, Italy [ 2 ] Scuola Normale Super Pisa, I-56127 Pisa, Italy [ 3 ] Ist Italiano Tecnol, Nanotechnol Innovat NEST, I-56127 Pisa, Italy (literal)

Titolo

Unveiling LOX-1 receptor interplay with nanotopography: mechanotransduction and atherosclerosis onset (literal)

Abstract

Lectin-like ox-LDL receptors (LOX-1) play a crucial role in the ox-LDL-induced pathological transformation of vessel-wall components, a crucial early step in atherogenesis. LOX-1 dynamics is quantitatively investigated in human endothelial cells (HUVECs) exposed to environmental nanotopographies. We demonstrate distinct nanotopography-induced cell phenotypes, characterized by different morphology, LOX-1 diffusivity and oligomerization state: HUVECs on flat surfaces exhibit the behavior found in pro-atherogenic conditions, while growth on nanogratings can interfere with LOX-1 dynamics and lead to a behavior characteristic of normal, non-pathological conditions. (literal)

Editore