http://www.cnr.it/ontology/cnr/individuo/prodotto/ID260793

Spherical gelatin/CNTs hybrid microgels as electro-responsive drug delivery systems (Articolo in rivista)

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Spherical gelatin/CNTs hybrid microgels as electro-responsive drug delivery systems (Articolo in rivista) (literal)

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Alternative label

Spizzirri U. G. [ 1 ] ; Hampel S. [ 2 ] ; Cirillo G. [ 1,2 ] ; Nicoletta F. P. [ 1,3 ] ; Hassan A. [ 2,4 ] ; Vittorio O. [ 5,6 ] ; Picci N. [ 1 ] ; Iemma F. [ 1 ] (2013)
Spherical gelatin/CNTs hybrid microgels as electro-responsive drug delivery systems
in International journal of pharmaceutics (Print); ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Spizzirri U. G. [ 1 ] ; Hampel S. [ 2 ] ; Cirillo G. [ 1,2 ] ; Nicoletta F. P. [ 1,3 ] ; Hassan A. [ 2,4 ] ; Vittorio O. [ 5,6 ] ; Picci N. [ 1 ] ; Iemma F. [ 1 ] (literal)

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[ 1 ] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, CS, Italy [ 2 ] Leibniz Inst Solid State & Mat Res Dresden, D-01171 Dresden, Germany [ 3 ] Univ Calabria, Dept Chem & Chem Technol, I-87036 Arcavacata Di Rende, CS, Italy [ 4 ] Fayoum Univ, Fac Sci, Dept Phys, Al Fayyum 63514, Egypt [ 5 ] NEST Scuola Normale Super, I-56126 Pisa, Italy [ 6 ] CNR, Ist Nanosci, I-56126 Pisa, Italy (literal)

Titolo

Spherical gelatin/CNTs hybrid microgels as electro-responsive drug delivery systems (literal)

Abstract

Novel spherical hybrid hydrogels composed of gelatin and multi-walled carbon nanotubes were synthesized by emulsion polymerization in the presence of sodium methacrylate and N,N'-ethylenebisacrylamide, and proposed as drug delivery microspheres for the electro-responsive release of Diclofenac sodium salt. Different amounts of nanotubes (up to 35% by weight) were covalently inserted into the polymeric network in order to determine the percentage conferring the highest electric sensitivity to the composite microspheres. Characterization of hydrogels was performed by electrical, morphological and calorimetric analyses, Raman measurements, biocompatibility assays and evaluation of the swelling behaviors in water (pH 1.0 and pH 7.4) with and without the application of an external electric field. Finally, the release profiles were determined and the diffusion behavior was evaluated by semi-empirical equations. (literal)

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