Modulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Modulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs. (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3109/00498254.2012.756558 (literal)

Alternative label

• Puccinelli E, Gervasi PG, Pelosi G, Puntoni M, Longo V. (2013)
  Modulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs.
  in Xenobiotica (Lond., Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Puccinelli E, Gervasi PG, Pelosi G, Puntoni M, Longo V. (literal)

Pagina inizio

• 686 (literal)

Pagina fine

• 698 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://informahealthcare.com/doi/abs/10.3109/00498254.2012.756558 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 43 (literal)

Rivista

• Xenobiotica (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 12 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 8 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Clinical Physiology - IFC, Pisa, Italy IBBA-Pisa (literal)

Titolo

• Modulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs. (literal)

Abstract

• 1. To date, no information has been available on the modulation of cytochrome P450 enzymes (CYPs) following the administration of a hyperlipidemic diet in pigs. 2. We investigated the potential modulation of xenobiotic-metabolizing CYPs in liver, heart and duodenum of pigs subjected to a high-fat/high-cholesterol diet for 2 months continuously (C-HFD) or on alternate weeks (A-HFD). 3. The administration of the high-fat diet resulted in considerably increased plasma cholesterol levels although the animals were still able to manage the lipid overload efficiently, and no sign of effective tissue inflammation occurred in livers. Plasma lipid profile and liver histology indicated a better adaptive response of the A-HFD pigs compared to the C-HFD group. We showed a post-transcriptional induction of hepatic CYP2E1 activity in C-HFD pigs and a transcriptional induction of hepatic CYP3As - especially in the A-HFD group. No further CYP modulation was observed in either liver or extra-hepatic tissues. 4. In conclusion, the administration of a high-fat diet in pigs resulted in limited effects on the drug metabolism system. The better adaptive response of A-HFD pigs compared to C-HFD pigs is a very interesting observation since the intermittent administration of the diet reflects the mode of human behavior more closely. (literal)

Prodotto di

• Institute of agricultural biology and biotechnology (IBBA) (Istituto)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• MARIARITA PUNTONI (Persona)
• VINCENZO LONGO (Unità di personale interno)
• PIER GIOVANNI GERVASI (Unità di personale interno)
• GUALTIERO PELOSI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Modulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of agricultural biology and biotechnology (IBBA) (Istituto)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR di

• GUALTIERO PELOSI (Unità di personale interno)
• PIER GIOVANNI GERVASI (Unità di personale interno)
• VINCENZO LONGO (Unità di personale interno)
• MARIARITA PUNTONI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Xenobiotica (Rivista)

Insieme di parole chiave di

• Parole chiave di "Modulation of cytochrome P450 enzymes in response to continuous or intermittent high-fat diet in pigs." (Insieme di parole chiave)