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Plasma leptin and vascular endothelial growth factor (VEGF) in normal subjects at high altitude (5050 m). (Articolo in rivista)

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Plasma leptin and vascular endothelial growth factor (VEGF) in normal subjects at high altitude (5050 m). (Articolo in rivista) (literal)

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G. Morici1,2, A. Bonanno2, A. Licciardi1, G. Valli3, C. Passino4, D. Bonardi5, N. Locorotondo7, M. Profita2, P. Palange3,7, A. Cogo8, and M.R. Bonsignore2,9 (2013)
Plasma leptin and vascular endothelial growth factor (VEGF) in normal subjects at high altitude (5050 m).
in Archives of physiology and biochemistry
(literal)

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G. Morici1,2, A. Bonanno2, A. Licciardi1, G. Valli3, C. Passino4, D. Bonardi5, N. Locorotondo7, M. Profita2, P. Palange3,7, A. Cogo8, and M.R. Bonsignore2,9 (literal)

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1Department of Experimental Biomedicine and Clinical Neuroscience (BIONeC), University of Palermo, Italy, 2Institute of Biomedicine and Molecular Immunology (IBIM), CNR, Palermo, Italy, 3Department of Clinical Medicine, University La Sapienza, Rome, Italy, 4Institute of Clinical Physiology, CNR, Pisa, Italy, 5Institute of Respiratory Disease, IRCCS, University of Milan, Italy, 6Locorotondo Research Laboratory, Palermo, Italy, 7Fondazione Lorrillard-Spencer Cenci, Rome, Italy, 8Department of Clinical and Experimental Medicine, Section of Respiratory Diseases, University of Ferrara, Italy, and 9Biomedical Department of Internal and Specialist Medicine (DiBiMIS), Pneumology Section, University of Palermo, Italy (literal)

Titolo

Plasma leptin and vascular endothelial growth factor (VEGF) in normal subjects at high altitude (5050 m). (literal)

Abstract

Context: High altitude (HA) is a model of severe hypoxia exposure in humans. We hypothesized that nocturnal hypoxemia or acute maximal exercise at HA might affect plasma leptin and VEGF levels. Objectives: Plasma leptin, VEGF and other metabolic variables were studied after nocturnal pulse oximetry and after maximal exercise in healthy lowlanders on the 3rd-4th day of stay in Lobuche (5050 m, HA) and after return to sea level (SL). Results: Leptin was similar at SL or HA in both pre- and post-exercise conditions. Pre-exercise VEGF at HA was lower, and cortisol was higher, than at SL, suggesting that nocturnal intermittent hypoxia associated with periodic breathing at HA might affect these variables. Conclusions: Leptin levels appear unaffected at HA, whereas nocturnal hypoxic stress may affect plasma VEGF. Future HA studies should investigate the possible role of nocturnal intermittent hypoxemia on metabolism (literal)

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