The mitochondrial genome encodes abundant small noncoding RNAs. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• The mitochondrial genome encodes abundant small noncoding RNAs. (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Alternative label

• Ro S, Ma HY, Park C, Ortogero N, Song R, Hennig GW, Zheng H, Lin YM, Moro L, Hsieh JT, Yan W (2013)
  The mitochondrial genome encodes abundant small noncoding RNAs.
  in Cell Research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ro S, Ma HY, Park C, Ortogero N, Song R, Hennig GW, Zheng H, Lin YM, Moro L, Hsieh JT, Yan W (literal)

Pagina inizio

• 759 (literal)

Pagina fine

• 774 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Cell Research (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA; 2Department of Urology, College of Medicine, National Cheng Kung University, 138 Sheng Li Road, Tainan 70403, China; 3Institute of Biomembranes and Bioenergetics, National Research Council (CNR), Bari 70123, Italy; 4Department of Urology, Southwestern Medical Center, University of Texas, Dallas, TX 75235, USA (literal)

Titolo

• The mitochondrial genome encodes abundant small noncoding RNAs. (literal)

Abstract

• Small noncoding RNAs identified thus far are all encoded by the nuclear genome. Here, we report that the murine and human mitochondrial genomes encode thousands of small noncoding RNAs, which are predominantly derived from the sense transcripts of the mitochondrial genes (host genes), and we termed these small RNAs mitochondrial genome-encoded small RNAs (mitosRNAs). DICER inactivation affected, but did not completely abolish mitosRNA production. MitosRNAs appear to be products of currently unidentified mitochondrial ribonucleases. Overexpression of mitosRNAs enhanced expression levels of their host genes in vitro, and dysregulated mitosRNA expression was generally associated with aberrant mitochondrial gene expression in vivo. Our data demonstrate that in addition to 37 known mitochondrial genes, the mammalian mitochondrial genome also encodes abundant mitosRNAs, which may play an important regulatory role in the control of mitochondrial gene expression in the cell. (literal)

Prodotto di

• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)
• Institute of biomembrane and bioenergetics (IBBE) (Istituto)

Autore CNR

• LOREDANA MORO (Persona)

Incoming links:

Prodotto

• Institute of biomembrane and bioenergetics (IBBE) (Istituto)
• Interrelazione nucleo/citoplasma/mitocondri nell'omeostasi cellulare. (SV.P15.003.001) (Modulo)

Autore CNR di

• LOREDANA MORO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cell Research (Rivista)