Functional Impact of Dendritic Branch-Point Morphology (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Functional Impact of Dendritic Branch-Point Morphology (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1523/JNEUROSCI.3495-12.2013 (literal)

Alternative label

• Ferrante M, Migliore M, Ascoli GA (2013)
  Functional Impact of Dendritic Branch-Point Morphology
  in The Journal of neuroscience; Society of Neuroscience, Washington (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ferrante M, Migliore M, Ascoli GA (literal)

Pagina inizio

• 2156 (literal)

Pagina fine

• 2165 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.jneurosci.org/content/33/5/2156 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 33 (literal)

Rivista

• ?The ?Journal of neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Center for Neural Informatics, Structures, and Plasticity, and Molecular Neuroscience Department, Krasnow Institute for Advanced Study, George Mason University, Fairfax, Virginia 22030; Institute of Biophysics, National Research Council, I-90146 Palermo, Italy (literal)

Titolo

• Functional Impact of Dendritic Branch-Point Morphology (literal)

Abstract

• Cortical pyramidal cells store multiple features of complex synaptic input in individual dendritic branches and independently regulate the coupling between dendritic and somatic spikes. Branch points in apical trees exhibit wide ranges of sizes and shapes, and the large diameter ratio between trunk and oblique dendrites exacerbates impedance mismatch. The morphological diversity of dendritic bifurcations could thus locally tune neuronal excitability and signal integration. However, these aspects have never been investigated. Here, we first quantified the morphological variability of branch points from two-photon images of rat CA1 pyramidal neurons. We then investigated the geometrical features affecting spike initiation, propagation, and timing with a computational model validated by glutamate uncaging experiments. The results suggest that even subtle membrane readjustments at branch points could drastically alter the ability of synaptic input to generate, propagate, and time action potentials. (literal)

Editore

• Society of Neuroscience (Editore)

Prodotto di

• Modelli di Organizzazione e Dinamica di Sistemi Complessi (MD.P01.004.001) (Modulo)
• Istituto di biofisica (IBF) (Istituto)

Autore CNR

• MICHELE MIGLIORE (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di biofisica (IBF) (Istituto)
• Modelli di Organizzazione e Dinamica di Sistemi Complessi (MD.P01.004.001) (Modulo)

Autore CNR di

• MICHELE MIGLIORE (Unità di personale interno)

Editore di

• Society of Neuroscience (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?Journal of neuroscience (Rivista)