Novel imino thioether complexes of platinum(II): Synthesis, structural investigation, and biological activity (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Novel imino thioether complexes of platinum(II): Synthesis, structural investigation, and biological activity (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/ic3024452 (literal)

Alternative label

• Sgarbossa P.; Sbovata S.M.; Bertani R.; Mozzon M.; Benetollo F.; Marzano C.; Gandin V.; Michelin R.A. (2013)
  Novel imino thioether complexes of platinum(II): Synthesis, structural investigation, and biological activity
  in Inorganic chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Sgarbossa P.; Sbovata S.M.; Bertani R.; Mozzon M.; Benetollo F.; Marzano C.; Gandin V.; Michelin R.A. (literal)

Pagina inizio

• 5729 (literal)

Pagina fine

• 5741 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://pubs.acs.org/doi/pdf/10.1021/ic3024452 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 52 (literal)

Rivista

• Inorganic chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 10 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1,2,3,4,8 : Department of Industrial Engineering, University of Padua, Via F. Marzolo, 9, 35131 Padua, Italy / 5 : ICIS, CNR, Corso Stati Uniti, 4-35100 Padua, Italy / 6,7 : Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, I-35131 Padova, Italy / 3 : C.N.R.-ISTM, Istituto di Scienze e Tecnologie Molecolari, Via F. Marzolo 1, I- 35131 Padova, Italy (literal)

Titolo

• Novel imino thioether complexes of platinum(II): Synthesis, structural investigation, and biological activity (literal)

Abstract

• The reactions of the nitrile complexes cis- and trans-[PtCl2(NCR)2] (R = Me, Et, CH2Ph, Ph) with an excess of ethanethiol, EtSH, in the presence of a catalytic amount of n-BuLi in tetrahydrofuran (THF), afforded in good yield the bis-imino thioether derivatives cis-[PtCl2{E-N(H)?C(SEt)R}2] (R = Me (1), Et (2), CH2Ph (3), Ph (4)) and trans-[PtCl2{E-N(H)?C(SEt)R}2] (R = Me (5), Et (6), CH2Ph (7), Ph (8)). The imino thioether ligands assumed the E configuration corresponding to a cis addition of the thiol to the nitrile triple bond. The spectroscopic properties of these complexes have been reported along with the molecular structures of 1, 2, and 7 as established by X-ray crystallography which indicated that these compounds exhibit square-planar coordination geometry around the platinum center. Four N-H···Cl intermolecular contacts (N-H···Cl ca. 2.5-2.7 Å) between each chlorine atom and the N-H proton of the imino thioether ligand gave rise to \"dimers\" Pt2Cl4L4 (L = imino thioether) formed by two PtCl2L2 units. The cytotoxic properties of these new platinum(II) complexes were evaluated against various human cancer cell lines. Among all derivatives, trans-[PtCl2{E-N(H)?C(SEt)CH2Ph}2] showed the greatest in vitro cytotoxic activity being able to decrease cancer cell viability roughly 3-fold more effectively than cisplatin. (literal)

Prodotto di

• Progettazione e sintesi di sistemi molecolari inorganici per diagnosi e terapia (PM.P01.019.002) (Modulo)
• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)
• Institute of Condensed Matter Chemistry and Energy Technologies (ICMATE) (Istituto)
• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)

Autore CNR

• FRANCO BENETOLLO (Unità di personale interno)
• ROBERTA BERTANI (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Novel imino thioether complexes of platinum(II): Synthesis, structural investigation, and biological activity" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di scienze e tecnologie molecolari (ISTM) (Istituto)
• Istituto di chimica inorganica e delle superfici (ICIS) (Istituto)
• Institute of Condensed Matter Chemistry and Energy Technologies (ICMATE) (Istituto)
• Progettazione e sintesi di sistemi molecolari inorganici per diagnosi e terapia (PM.P01.019.002) (Modulo)

Autore CNR di

• FRANCO BENETOLLO (Unità di personale interno)
• ROBERTA BERTANI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Inorganic chemistry (Rivista)

Insieme di parole chiave di

• Keywords of "Novel imino thioether complexes of platinum(II): Synthesis, structural investigation, and biological activity" (Insieme di parole chiave)