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Computational analysis of current and noise properties of a single open ion channel (Articolo in rivista)

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Computational analysis of current and noise properties of a single open ion channel (Articolo in rivista) (literal)

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Piccinini, E; Affinito, F; Brunetti, R; Jacoboni, C; Rudan, M (2007)
Computational analysis of current and noise properties of a single open ion channel
in Journal of chemical theory and computation
(literal)

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Univ Modena, Consiglio Nazl Ric, Inst Nazl Fis Mat S Res Ctr 3, I-41100 Modena, Italy; Univ Modena, Dipartimento Fis, I-41100 Modena, Italy; Univ Bologna, Alma Mater Studiorum, Adv Res Ctr Elect Syst, Bologna, Italy; Univ Bologna, Dipartimento Ingn Elett Informat & Sistemist, Bologna, Italy (literal)

Titolo

Computational analysis of current and noise properties of a single open ion channel (literal)

Abstract

This paper presents a computational analysis of the noise associated with the ion current in single open ion channels. The study is performed by means of a coupled molecular dynamics/Monte Carlo approach able to simulate the conduction process on the basis of all microscopic information today available from protein structural data and atomistic simulations. The case of potassium ions permeating the KcsA channel is considered in the numerical calculations. The results show a noise spectrum different from what is theoretically predicted for Poisson noise, confirmed by the existence of a correlation in ion-exit events. (literal)

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