Predictive value of pre-therapy 18F-FDG PET/CT for the outcome of 18F-FDG PET-guided radiotherapy in patients with head and neck cancer (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Predictive value of pre-therapy 18F-FDG PET/CT for the outcome of 18F-FDG PET-guided radiotherapy in patients with head and neck cancer (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00259-013-2528-2 (literal)

Alternative label

• Maria Picchio; M. Kirienko; Paola Mapelli; Italo Dell'Oca; Eugenio Villa; Francesca Gallivanone; Luigi Gianolli; Cristina Messa; Isabella Castiglioni (2014)
  Predictive value of pre-therapy 18F-FDG PET/CT for the outcome of 18F-FDG PET-guided radiotherapy in patients with head and neck cancer
  in European journal of nuclear medicine and molecular imaging (Internet)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Maria Picchio; M. Kirienko; Paola Mapelli; Italo Dell'Oca; Eugenio Villa; Francesca Gallivanone; Luigi Gianolli; Cristina Messa; Isabella Castiglioni (literal)

Pagina inizio

• 21 (literal)

Pagina fine

• 31 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Pubblicato on-line: 29 Agosto 2013. I.F. 2012 5.114 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 41 (literal)

Rivista

• European journal of nuclear medicine and molecular imaging (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Nuclear Medicine, Scientific Institute San Raffaele, Milan, Italy. Institute for Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR), Segrate, Milan, Italy. University of Milano-Bicocca, Milan, Italy. Radiation Oncology Department, Scientific Institute San Raffaele, Milan, Italy. Tecnomed Foundation, University of Milano-Bicocca, Milan, Italy. Department of Nuclear Medicine, San Gerardo Hospital, Monza, Italy. (literal)

Titolo

• Predictive value of pre-therapy 18F-FDG PET/CT for the outcome of 18F-FDG PET-guided radiotherapy in patients with head and neck cancer (literal)

Abstract

• PURPOSE: The aim of this study was to evaluate the predictive role of pre-therapy fluorodeoxyglucose (FDG) uptake parameters of primary tumour in head and neck cancer (HNC) patients undergoing intensity-modulated radiotherapy (IMRT) with simultaneous integrated boost (SIB) on FDG-positive volume-positron emission tomography (PET) gross tumour volume (PET-GTV). METHODS: This retrospective study included 19 patients (15 men and 4 women, mean age 59.2 years, range 23-81 years) diagnosed with HNC between 2005 and 2011. Of 19 patients, 15 (79 %) had stage III-IV. All patients underwent FDG PET/CT before treatment. Metabolic indexes of primary tumour, including metabolic tumour volume (MTV), maximum and mean standardized uptake value (SUVmax, SUVmean) and total lesion glycolysis (TLG) were considered. Partial volume effect correction (PVC) was performed for SUVmean and TLG estimation. Correlations between PET/CT parameters and 2-year disease-free survival (DFS), local recurrence-free survival (LRFS) and distant metastasis-free survival (DMFS) were assessed. Median patient follow-up was 19.2 months (range 4-24 months). RESULTS: MTV, TLG and PVC-TLG predicting patients' outcome with respect to all the considered local and distant disease control endpoints (LRFS, DMFS and DFS) were 32.4 cc, 469.8 g and 547.3 g, respectively. SUVmean and PVC-SUVmean cut-off values predictive of LRFS and DFS were 10.8 and 13.3, respectively. PVC was able to compensate errors up to 25 % in the primary HNC tumour uptake. Moreover, PVC enhanced the statistical significance of the results. CONCLUSION: FDG PET/CT uptake parameters are predictors of patients' outcome and can potentially identify patients with higher risk of treatment failure that could benefit from more aggressive approaches. Application of PVC is recommended for accurate measurement of PET parameters. (literal)

Prodotto di

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Imaging molecolare e proteogenomica (ME.P06.026.001) (Modulo)

Autore CNR

• MARIA CRISTINA MESSA (Unità di personale esterno)
• FRANCESCA GALLIVANONE (Persona)
• MARIA PICCHIO (Unità di personale esterno)
• ISABELLA CASTIGLIONI (Persona)

Insieme di parole chiave

• Keywords of "Predictive value of pre-therapy 18F-FDG PET/CT for the outcome of 18F-FDG PET-guided radiotherapy in patients with head and neck cancer" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• MARIA CRISTINA MESSA (Unità di personale esterno)
• ISABELLA CASTIGLIONI (Persona)
• MARIA PICCHIO (Unità di personale esterno)
• FRANCESCA GALLIVANONE (Persona)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Imaging molecolare e proteogenomica (ME.P06.026.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• European journal of nuclear medicine and molecular imaging (Rivista)

Insieme di parole chiave di

• Keywords of "Predictive value of pre-therapy 18F-FDG PET/CT for the outcome of 18F-FDG PET-guided radiotherapy in patients with head and neck cancer" (Insieme di parole chiave)