http://www.cnr.it/ontology/cnr/individuo/prodotto/ID254580
Fennel allergy is a lipid-transfer protein (LTP)-related food hypersensitivity associated with peach allergy (Articolo in rivista)
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- Fennel allergy is a lipid-transfer protein (LTP)-related food hypersensitivity associated with peach allergy (Articolo in rivista) (literal)
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- 2013-01-01T00:00:00+01:00 (literal)
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- 10.1021/jf303291k (literal)
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Pastorello, E.A. Farioli, L. Stafylaraki, C. Scibilia, J. Giuffrida, M.G. Mascheri, A. Piantanida, M. Baro, C. Primavesi, L. Nichelatti, M. Schroeder, J.W. and Pravettoni, V. (2013)
Fennel allergy is a lipid-transfer protein (LTP)-related food hypersensitivity associated with peach allergy
in Journal of agricultural and food chemistry
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- Pastorello, E.A. Farioli, L. Stafylaraki, C. Scibilia, J. Giuffrida, M.G. Mascheri, A. Piantanida, M. Baro, C. Primavesi, L. Nichelatti, M. Schroeder, J.W. and Pravettoni, V. (literal)
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- Allergology and Immunology Unit, Niguarda Ca' Granda Hospital, 20162 Milan, Italy; Department of Laboratory Medicine, Niguarda Ca' Granda Hospital, 20162 Milan, Italy; Service of Biostatistics, Niguarda Ca' Granda Hospital, 20162 Milan, Italy; Institute of Sciences of Food Production (ISPA), National Research Council (CNR), c/o Bioindustry Park Silvano Fumero, 10010 Colleretto Giacosa (Turin), Italy; Clinical Allergy and Immunology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy (literal)
- Titolo
- Fennel allergy is a lipid-transfer protein (LTP)-related food hypersensitivity associated with peach allergy (literal)
- Abstract
- Fennel allergy has been rarely reported, and the association with peach allergy has never been described. Our aim was to (i) study the correlation between symptom severity of peach and fennel and (ii) identify fennel allergens and the role of rPru p 3 antibodies in severe reactions to fennel. In 148 patients with peach allergy, we investigated 58 patients with symptoms and IgE antibodies positive to fennel. IgE to rPru p 1, 3, and 4 and rBet v 1, 2, and 4 were measured by immunoblotting, and the N-terminal amino acid sequences and relevant allergens were determined. We found significant association between severe reactions to fennel and peach (p = 0.0009). A major allergen was ~9 kDa lipid-transfer protein (LTP), cross-reactive with Pru p 3, a 15 kDa protein identified as a pathogenesis-related protein 1 of the Bet v 1 family. In conclusion, peach and fennel severe allergic symptoms are significantly related, and LTP is a major fennel allergen. Fennel should be included in the LTP syndrome. © 2012 American Chemical Society. (literal)
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