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Detection of ganglioside clustering in DOPC bilayers by 1H-NMR spectroscopy (Articolo in rivista)

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Detection of ganglioside clustering in DOPC bilayers by 1H-NMR spectroscopy (Articolo in rivista) (literal)

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D'Emiliano, D; Casieri, C; Paci, M; De Luca, F (2007)
Detection of ganglioside clustering in DOPC bilayers by 1H-NMR spectroscopy
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Univ Roma La Sapienza, Res Ctr SOFT, INFM, CNR, I-00185 Rome, Italy; Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy; Univ Aquila, Dipartimento Fis, I-67010 Coppito, Italy; Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, I-00173 Rome, Italy (literal)

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Detection of ganglioside clustering in DOPC bilayers by 1H-NMR spectroscopy (literal)

Abstract

1H-NMR spectroscopy has been used to investigate the formation of GM1 clusters in DOPC liposome bilayer. The 1H-DOPC NMR spectra show that the presence of GM1 modifies some resonance lines. These modifications are imputable to the interaction of DOPC with GM1. Above a certain GM1 concentration the trend of such distortions suggests the formation of GM1 aggregates. This work provides a new and simple NMR proof of the GM1 clustering in DOPC liposomes and therefore on model cell membranes; it allows to estimate the mean size of GM1 aggregates and the GM1 concentration at which clustering starts. In addition, the behaviour of the 1H-NMR line-width shows that the presence of GM1 modifies the bilayer arrangement making it more mobile, especially at GM1-clustering concentration. (c) 2006 Published by Elsevier B.V. (literal)

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