Selection on codon bias in yeast: a transcriptional hypothesis (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Selection on codon bias in yeast: a transcriptional hypothesis (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1093/nar/gkt740 (literal)

Alternative label

• Edoardo Trotta (2013)
  Selection on codon bias in yeast: a transcriptional hypothesis
  in Nucleic acids research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Edoardo Trotta (literal)

Pagina inizio

• 9382 (literal)

Pagina fine

• 9395 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://nar.oxfordjournals.org/content/41/20/9382.full (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 41 (literal)

Rivista

• Nucleic acids research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 14 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 20 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Farmacologia Traslazionale CNR (literal)

Titolo

• Selection on codon bias in yeast: a transcriptional hypothesis (literal)

Abstract

• Codons that code for the same amino acid are often used with unequal frequencies. This phenomenon is termed codon bias. Here, we report a computational analysis of codon bias in yeast using experimental and theoretical genome-wide data. We show that the most used codons in highly expressed genes can be predicted by mRNA structural data and that the codon choice at each synonymous site within an mRNA is not random with respect to the local secondary structure. Because we also found that the folding stability of intron sequences is strongly correlated with codon bias and mRNA level, our results suggest that codon bias is linked to mRNA folding structure through a mechanism that, at least partially, operates before pre-mRNA splicing. Consistent with this, we report evidence supporting the adaptation of the tRNA pool to the codon profile of the most expressed genes rather than vice versa. We show that the correlation of codon usage with the gene expression level also includes the stop codons that are normally not decoded by aminoacyl-tRNAs. The results reported here are consistent with a role for transcriptional forces in driving codon usage bias via a mechanism that improves gene expression by optimizing mRNA folding structures. (literal)

Prodotto di

• Neurogenetica e basi molecolari delle atassie spinocerebellari (SCA), atassie episodiche (EA), corea ereditaria benigna (BHC) e demenze associate a depressione e/o a disturbi psico-comportamentali. (ME.P02.026.001) (Modulo)

Autore CNR

• EDOARDO TROTTA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Selection on codon bias in yeast: a transcriptional hypothesis" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• EDOARDO TROTTA (Unità di personale interno)

Prodotto

• Neurogenetica e basi molecolari delle atassie spinocerebellari (SCA), atassie episodiche (EA), corea ereditaria benigna (BHC) e demenze associate a depressione e/o a disturbi psico-comportamentali. (ME.P02.026.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nucleic acids research (Rivista)

Insieme di parole chiave di

• Parole chiave di "Selection on codon bias in yeast: a transcriptional hypothesis" (Insieme di parole chiave)