Synthetic procedures to monomethyl-platinum(II) complexes containing nitrogen ligands of biological relevance (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Synthetic procedures to monomethyl-platinum(II) complexes containing nitrogen ligands of biological relevance (Articolo in rivista) (literal)

Anno

• 2002-01-01T00:00:00+01:00 (literal)

Alternative label

• MONSU' SCOLARO L; MAZZAGLIA A; ROMEO A; ROMEO R (2002)
  Synthetic procedures to monomethyl-platinum(II) complexes containing nitrogen ligands of biological relevance
  in Journal of inorganic biochemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• MONSU' SCOLARO L; MAZZAGLIA A; ROMEO A; ROMEO R (literal)

Pagina inizio

• 237 (literal)

Pagina fine

• 245 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 91 (literal)

Rivista

• Journal of inorganic biochemistry (Rivista)

Note

• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Dipartimento di Chimica Inorganica, Chimica Analitica e Chimica Fisica , Università di Messina; CNR-ISMN UOS Palermo c/o Università di Messina (literal)

Titolo

• Synthetic procedures to monomethyl-platinum(II) complexes containing nitrogen ligands of biological relevance (literal)

Abstract

• The complex trans-bis(dimethylsulfoxide)chloromethylplatinum(II) (1) is fairly soluble in water, where it undergoes multiple equilibria involving the formation of geometrically distinct [Pt(H2O)(DMSO)Cl(CH3)] aqua-species. On reacting ail aqueous solution of 1 with monodentate nitrogen donor ligands L, such as pyridines or amines, two well distinct patterns of behavior can be recognized: (i) a single stage fast substitution of one DMSO by the entering ligand, yielding a complex of the type trans(C,N)-[Pt(DMSO)(L)Cl(CH3)] which contains four different groups coordinated to the metal and which undergoes a slow conversion into its cis-isomer, (ii) a double substitution affording cationic complex ions of the type cis- [Pt(L)(2) (DMSO)(CH3)](+). When this latter reaction is carried out using sterically hindered ligands, slow rotation of the bulk ligand around the Pt-N bond. allows for the identification of head-to-head and head-to-tail rotamers in solution, through H-1 NMR spectrometry. The addition of chloride anion to 1 leads to the anionic species cis-[Pt(DMSO)Cl-2(CH3)](-), where a molecule of DMSO still remains coordinated to the metal center, despite its quite fast rate of ligand exchange (k(exch) with free DMSO=12+/-1 s(-1)). The reaction of complex I with bidentate ligands, such as ethylenediamine (en) or simple amino acids, leads to the cationic species [Pt(en)(DMSO)(CH3)](+) or to the neutral [Pt(DMSO)(N-O)(CH3)], (where N-O=GlyO(-), AlaO(-)). (literal)

Prodotto di

• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)
• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)

Autore CNR

• ANTONINO MAZZAGLIA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Synthetic procedures to monomethyl-platinum(II) complexes containing nitrogen ligands of biological relevance" (Insieme di parole chiave)

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Prodotto

• Istituto per lo studio dei materiali nanostrutturati (ISMN) (Istituto)
• Sintesi e crescita di film e superfici nanostrutturate (PM.P05.004.002) (Modulo)

Autore CNR di

• ANTONINO MAZZAGLIA (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of inorganic biochemistry (Rivista)

Insieme di parole chiave di

• Parole chiave di "Synthetic procedures to monomethyl-platinum(II) complexes containing nitrogen ligands of biological relevance" (Insieme di parole chiave)