http://www.cnr.it/ontology/cnr/individuo/prodotto/ID2481

Structural models of human big conductance calcium- and voltage-gated potassium channels (Articolo in rivista)

Type

Label

Structural models of human big conductance calcium- and voltage-gated potassium channels (Articolo in rivista) (literal)

Anno

Alternative label

Kranjc, A; Anselmi, C; Carloni, P; Blaney, FE (2007)
Structural models of human big conductance calcium- and voltage-gated potassium channels
in Computer physics communications
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Pagina inizio

Pagina fine

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

Rivista

Note

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

SISSA, ISAS, I-34014 Trieste, Italy; CNR, INFM, DEMOCRITOS Modeling Ctr Res Atomist Simulat, I-34014 Trieste, Italy; IIT, SISSA Unit, I-34014 Trieste, Italy; GlaxoSmithKline Inc, Harlow CM19 5AW, Essex, England (literal)

Titolo

Structural models of human big conductance calcium- and voltage-gated potassium channels (literal)

Abstract

Human big conductance Ca2+- and voltage-gated K+ channels (hBK) are putative drug targets for cardiovascular, respiratory and urological diseases. Here we have used molecular simulation and bioinformatics approaches to construct models of two domains important for Ca2+ binding and channel gating, namely the regulator of conductance for K+ (RCK1) domain and the so-called calcium bowl (CB). As templates for RCK1 were used the corresponding domains from a K+ channel from E. coli and the K+ channel from Methanobacterium thermoautothropicum (MthK). CB was modeled upon the structure of the human thrombospondin-1 C-terminal fragment and allowing the domain to relax in a simulated aqueous environment for 10-ns molecular dynamics simulations. The relevance of these models for interpreting the available molecular biology data is then discussed. (C) 2007 Elsevier B.V. All rights reserved. (literal)

Prodotto di