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Synthetic Exploitation of the Ring-Opening of 3,4-Dinitrothiophene. Part 4. Synthesis of 1,4-Disubstituted 3-Hydroxyimino-2-nitro-1-butenes and their Cyclization to 4-Nitroisoxazoles (Articolo in rivista)
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- Synthetic Exploitation of the Ring-Opening of 3,4-Dinitrothiophene. Part 4. Synthesis of 1,4-Disubstituted 3-Hydroxyimino-2-nitro-1-butenes and their Cyclization to 4-Nitroisoxazoles (Articolo in rivista) (literal)
- Anno
- 1994-01-01T00:00:00+01:00 (literal)
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Dell'Erba C.; Novi M.; Petrillo G.; Stagnaro P. (1994)
Synthetic Exploitation of the Ring-Opening of 3,4-Dinitrothiophene. Part 4. Synthesis of 1,4-Disubstituted 3-Hydroxyimino-2-nitro-1-butenes and their Cyclization to 4-Nitroisoxazoles
in Journal of heterocyclic chemistry; WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ (Stati Uniti d'America)
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- Dell'Erba C.; Novi M.; Petrillo G.; Stagnaro P. (literal)
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- http://onlinelibrary.wiley.com/doi/10.1002/jhet.5570310429/pdf (literal)
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- Dell'Erba C.; Novi M.; Petrillo G. Università di Genova
Stagnaro P. Università di Genova (attualmente CNR-ISMAC Genova) (literal)
- Titolo
- Synthetic Exploitation of the Ring-Opening of 3,4-Dinitrothiophene. Part 4. Synthesis of 1,4-Disubstituted 3-Hydroxyimino-2-nitro-1-butenes and their Cyclization to 4-Nitroisoxazoles (literal)
- Abstract
- The reduction of a single nitrovinyl moiety in 1,4-dialkyl- and 1,4-diaryl-2,3-dinitro-1,3-butadienes 1 with stannous chloride dihydrate in ethyl acetate furnishes the corresponding 3-hydroximino-2-nitro-1-butenes 4 in satisfactory yields. The oxidative cyclization of the latter compounds gives variable yields of 3,5-disubstituted 4-nitroisoxazoles 5, most likely arising from aromatization of the corresponding 4,5-dihydroisoxazoles, formed through an intramolecular Michael addition of the hydroximino group in 4 to the nitroalkene functionality. In the case of the 1-naphthyl derivative 4d such oxidative cyclization mainly leads to the competitive formation of 3-[(1-naphthyl)methyl]-2-nitrobenzo[f]quinoline N-oxide 7. (literal)
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