Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1111/j.1582-4934.2010.01014.x. (literal)

Alternative label

• Forini F.; Lionetti V.; Ardehali H.; Pucci A.; Cecchetti F.; Ghanefar M.; Nicolini G.; Ichikawa Y.; Nannipieri M.; Recchia F.; Iervasi G. (2010)
  Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats
  in Journal of Cellular and Molecular Medicine (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Forini F.; Lionetti V.; Ardehali H.; Pucci A.; Cecchetti F.; Ghanefar M.; Nicolini G.; Ichikawa Y.; Nannipieri M.; Recchia F.; Iervasi G. (literal)

Pagina inizio

• 514 (literal)

Pagina fine

• 524 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 15 (literal)

Rivista

• Journal of Cellular and Molecular Medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: Journal of Molecular Medicine, vol. 20 pp. 1 - 11. Blackwell, 2010. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Clinical Physiology, CNR, Pisa, Italy, Institute of Clinical Physiology, CNR, Pisa, Sector of Medicine, Scuola Superiore Sant'Anna, Pisa,, Division of Cardiology, Feinberg Cardiovascular Institute, Northwestern University, Chicago, IL, USA, Division of Surgical, Molecular and Ultrastructural Pathology, Pisa University Hospital, Pisa, Department of Internal Medicine, University of Pisa and Pisa University Hospital, Sector of Medicine, Scuola Superiore Sant'Anna, Pisa, Department of Physiology, New York Medical College, Valhalla, NY, USA (literal)

Titolo

• Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats (literal)

Abstract

• 3,5,3-Levo-triiodothyronine (L-T3) is essential for DNA transcription, mitochondrial biogenesis and respiration, but its circulating levels rapidly decrease after myocardial infarction (MI). The main aim of our study was to test whether an early and sustained normalization of L-T3 serum levels after MI exerts myocardial protective effects through a mitochondrial preservation. Seventy-two hours after MI induced by anterior interventricular artery ligation, rats were infused with synthetic L-T3 (1.2 ?g/kg/day) or saline over 4 weeks. Compared to saline, L-T3 infusion restored FT3 serum levels at euthyroid state (6.5 ? 0.5 versus4.6 ? 0.3 pmol/l), improved left ventricular (LV) ejection fraction (39.5 ? 2.5 versus65.5 ? 6.9%), preserved LV end-systolic wall thickening in the peri-infarct zone (6.34 ? 3.1 versus33.7 ? 6.21%) and reduced LV infarct-scar size by approximately 50% (all P ? 0.05). Moreover, L-T3 significantly increased angiogenesis and cell survival and enhanced the expression of nuclear-encoded transcription factors involved in these processes. Finally, L-T3 significantly increased the expression of factors involved in mitochondrial DNA transcription and biogenesis, such as hypoxic inducible factor-1?, mitochondrial transcription factor A and peroxisome proliferator activated receptor ? coactivator-1?, in the LV periinfarct zone. To further explore mechanisms of L-T3 protective effects, we exposed isolated neonatal cardiomyocytes to H2O2 and found that L-T3 rescued mitochondrial biogenesis and function and protected against cell death viaa mitoKATP dependent pathway. Early and sustained physiological restoration of circulating L-T3 levels after MI halves infarctscar size and prevents the progression towards heart failure. This beneficial effect is likely due to enhanced capillary formation and mitochondrial protection. (literal)

Prodotto di

• Epidemiologia Sociale (ME.P07.016.002) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• GIORGIO IERVASI (Unità di personale interno)
• GIUSEPPINA NICOLINI (Persona)
• FRANCESCA FORINI (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• Epidemiologia Sociale (ME.P07.016.002) (Modulo)

Autore CNR di

• GIORGIO IERVASI (Unità di personale interno)
• FRANCESCA FORINI (Unità di personale interno)
• GIUSEPPINA NICOLINI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of Cellular and Molecular Medicine (Rivista)

Insieme di parole chiave di

• Parole chiave di "Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats" (Insieme di parole chiave)