Contribution of Glucose Tolerance and Gender to Cardiac Adiposity. (Articolo in rivista)

Type
Label
  • Contribution of Glucose Tolerance and Gender to Cardiac Adiposity. (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1210/jc.2009-0436 (literal)
Alternative label
  • Iozzo P, Lautamaki R, Borra R, Lehto HR, Bucci M, Viljanen A, Parkka J, Lepomaki V, Maggio R, Parkkola R, Knuuti J, Nuutila P. (2009)
    Contribution of Glucose Tolerance and Gender to Cardiac Adiposity.
    in The Journal of clinical endocrinology and metabolism; Endocrine Society, Chevy Chase (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Iozzo P, Lautamaki R, Borra R, Lehto HR, Bucci M, Viljanen A, Parkka J, Lepomaki V, Maggio R, Parkkola R, Knuuti J, Nuutila P. (literal)
Pagina inizio
  • 4472 (literal)
Pagina fine
  • 4482 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://jcem.endojournals.org/content/94/11/4472.long (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 94 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Turku PET Centre (P.I., R.L., R.B., H.-R.L., M.B., A.V., V.L., R.M., J.K., P.N.) and Departments of Radiology (R.B., R.P.), Clinical Physiology (J.P.), and Medicine (P.N.), University of Turku, 20521 Turku, Finland; and Institute of Clinical Physiology (P.I., M.B.), National Research Council, 56124 Pisa, Italy (literal)
Titolo
  • Contribution of Glucose Tolerance and Gender to Cardiac Adiposity. (literal)
Abstract
  • Context and Objective: To examine whether pericardial and myocardial fat depots may contribute to the association between diabetes and cardiovascular risk, including sex-related differences, and the role of adiponectin, we evaluated data in patients with obesity and without diabetes [nondiabetic (ND)] or with impaired glucose tolerance or type 2 diabetes and in lean ND controls. Methods: Magnetic resonance imaging and spectroscopy were used to measure left ventricular (LV) function and abdominal sc and visceral fat areas to estimate respective masses, pericardial fat depots, and myocardial triglyceride content in 53 subjects (10 lean ND, 25 obese ND, six impairedglucose- tolerance, and 12 type 2 diabetic patients with macrovascular disease); gender effects and adiponectin levels were evaluated in the available subset of subjects. Results: Myocardial and pericardial fat increased progressively across study groups. They were lower in obesewomenthanmen(P?0.002), but cardiac steatosis caughtupin hyperglycemicwomen(?81% vs. ND, P ? 0.01). Adiponectin was inversely related with both fat depots (P ? 0.01) and LV mass (P ? 0.003) and positively with LV function (P ? 0.03). In multiple regression analysis, myocardial and pericardial fat were independently related with plasma glucose levels, only pericardial fat mass was associated with visceral adiposity and myocardial fat with cardiac output and work. Conclusions:Weconclude that glycemia, gender, adiponectin,andcardiac workload are associated with, and hyperglycemia and male gender are independent positive predictors of, heart adiposity. Once glucose tolerance becomes impaired, the evolution of cardiac steatosis is more pronounced in women. (J Clin Endocrinol Metab 94: 4472-4482, 2009) (literal)
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