miRNAs couple cell fate and developmental timing in retina (Articolo in rivista)

Type
Label
  • miRNAs couple cell fate and developmental timing in retina (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1073/pnas.0909167106 (literal)
Alternative label
  • Decembrini S, Bressan D, Bignali R, Pitto L, Mariotti S, Rainaldi G, Wang X, Evangelista M, Barsacchi G, Cremisi F. (2009)
    miRNAs couple cell fate and developmental timing in retina
    in Proceedings of the National Academy of Sciences of the United States of America
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Decembrini S, Bressan D, Bignali R, Pitto L, Mariotti S, Rainaldi G, Wang X, Evangelista M, Barsacchi G, Cremisi F. (literal)
Pagina inizio
  • 21179 (literal)
Pagina fine
  • 21184 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.pnas.org (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 106 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 50 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Biologia, Universita` di Pisa, Pisa, Italy; Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, Italy; Scuola Normale Superiore Pisa, Classe di Scienze, Pisa, Italy; Center for Brain and Cognitive Sciences, Institute of Biophysics, Beijing, China (literal)
Titolo
  • miRNAs couple cell fate and developmental timing in retina (literal)
Abstract
  • Cell identity is acquired in different brain structures according to a stereotyped timing schedule, by accommodating the proliferation of multipotent progenitor cells and the generation of distinct types of mature nerve cells at precise times. However, the molecular mechanisms coupling the identity of a specific neuron and its birth date are poorly understood. In the neural retina, only late progenitor cells that divide slowly can become bipolar neurons, by the activation of otx2 and vsx1 genes. In Xenopus, we found that Xotx2 and Xvsx1 translation is inhibited in early progenitor cells that divide rapidly by a set of cell cycle-related microRNAs (miRNAs). Through expression and functional screenings, we selected 4 miRNAs--mir-129, mir-155, mir-214, and mir-222--that are highly expressed at early developmental stages in the embryonic retina and bind to the 3' UTR of Xotx2 and Xvsx1 mRNAs inhibiting their translation. The functional inactivation of these miRNAs in vivo releases the inhibition, supporting the generation of additional bipolar cells. We propose a model in which the proliferation rate and the age of a retinal progenitor are linked to each other and determine the progenitor fate through the activity of a set of miRNAs. (literal)
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