Reduction of blood coagulation and monocyte-platelet interaction following the use of a minimal extracorporeal circulation system (Synergy) in coronary artery bypass grafting (CABG) (Articolo in rivista)

Type
Label
  • Reduction of blood coagulation and monocyte-platelet interaction following the use of a minimal extracorporeal circulation system (Synergy) in coronary artery bypass grafting (CABG) (Articolo in rivista) (literal)
Anno
  • 2008-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1177/0267659108091336 (literal)
Alternative label
  • Farneti P. A.; Sbrana S.; Spiller D.; Cerillo A. G.; Santarelli F.; Di Dario D.; Del Sarto P. A.; Glauber M. (2008)
    Reduction of blood coagulation and monocyte-platelet interaction following the use of a minimal extracorporeal circulation system (Synergy) in coronary artery bypass grafting (CABG)
    in Perfusion (Münch.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Farneti P. A.; Sbrana S.; Spiller D.; Cerillo A. G.; Santarelli F.; Di Dario D.; Del Sarto P. A.; Glauber M. (literal)
Pagina inizio
  • 49 (literal)
Pagina fine
  • 56 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 23 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: Perfusion, vol. 23 (1) pp. 49 - 56. Prakash P. Punjabi (ed.). SAGE Publications, 2008. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IFC-CNR - Fondazione G. Monasterio, Massa Carrara, CNR-IFC, Massa Carrara (literal)
Titolo
  • Reduction of blood coagulation and monocyte-platelet interaction following the use of a minimal extracorporeal circulation system (Synergy) in coronary artery bypass grafting (CABG) (literal)
Abstract
  • Cardiovascular surgery with cardiopulmonary bypass (CPB) induces activation of blood coagulation and systemic inflammation involved in post-operative complications. Our study evaluated the impact of the minimal extracorporeal circulation (mini-CPB) system (Synergy®, Sorin Group) on these functional aspects. Twenty patients were randomly assigned to standard CPB (n=10) or to Synergy (n=10). Platelet expression of PAC-1, and monocyte/granulocyte-platelet conjugates were evaluated by flow cytometry. A leukocyte-platelet adhesion index was calculated after cell number normalization. ELISAs were performed to measure IL-6 and TNF-a, thrombinantithrombin III complexes (TAT), prothrombin fragments (F1+2), ß-thromboglobulin (ß-TG) and sP-selectin (sCD62P). Blood samples were drawn at the time of anesthesia (T1), at the end of CPB (T2), and at 4 (T3) and 24 hours (T4) after weaning from CPB. All patients were similar for clinical characteristics. When compared to standard CPB, the Synergy showed lower levels of the monocyte-platelet adhesion index at T2 (0.023 ± 0.005 vs 0.063 ± 0.013, P = 0.0092) and T4 (0.031 ± 0.003 vs 0.055 ± 0.005, P = 0.0017), TAT complexes at T2 (27.175 ± 5.967 vs 86.592 ± 5.415, P = 0.0005) and T3 (26.977 ± 2.468 vs 45.146 ± 4.365, P = 0.0041), F1+2 fragments at T2 (2.222 ± 0.226 vs 4.249 ± 0.292, P = 0.0009), and sP-selectin at T3 (115.17 ± 19.623 vs 169.554 ± 19.709, P = 0.0703) and T4 (108.542 ± 6.429 vs 140.799 ± 14.771, P = 0.0833). In summary,the Synergy exhibited a lower post-operative activationof blood coagulation, together with a reduced interaction between circulating monocytes and platelets. (literal)
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