Perturbation of murine liver cyp-superfamily of isoforms by di different combinations of pesticide mixtures (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Perturbation of murine liver cyp-superfamily of isoforms by di different combinations of pesticide mixtures (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Alternative label

• Canistro D.; Pozzetti L.; Sapone A.; Broccoli M.; Affatato A.; Stradiotti A.; Longo V.; Menichini P.; Barale R.; Paolini M. (2008)
  Perturbation of murine liver cyp-superfamily of isoforms by di different combinations of pesticide mixtures
  in Food and chemical toxicology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Canistro D.; Pozzetti L.; Sapone A.; Broccoli M.; Affatato A.; Stradiotti A.; Longo V.; Menichini P.; Barale R.; Paolini M. (literal)

Pagina inizio

• 34 (literal)

Pagina fine

• 42 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 46 (literal)

Rivista

• Food and chemical toxicology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: Food and Chemical Toxicology, vol. 46 pp. 34 - 42. Elsevier, 2008. (literal)

Note

• ISI Web of Science (WOS) (literal)

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• Department of Pharmacology, Molecular Toxicology Unit, Alma Mater Studiorum-University of Bologna, Bologna,Italy. Laboratory of Pharmacogenetic and Drug Metabolism, CNR Clinical Physiology Institute, Pisa,Italy. Department of Human and Environmental Sciences,University of Pisa, Pisa,Italy, CNR-IFC, Pisa (literal)

Titolo

• Perturbation of murine liver cyp-superfamily of isoforms by di different combinations of pesticide mixtures (literal)

Abstract

• It was previously found that fenarimol,vinclozolin or acephate,three of the most used pesticides worldwide,provoked a marked per- turbation of murine cytochrome P450 (CYP)-linked monooxygenases.Here,to more closely mimic human exposure,it was investigated whether di ?erent pesticide combinations administered i .p .in male Swiss Albino CD1 mice in single or repeated fashion (daily,for three consecutive days),a ?ect CYP-dependent oxidations.The four simulated mixtures showed a complex pattern of CYP induction and suppression,especially after repeated injection.For example,while fenarimol alone was the most inducing agent -reaching a 79-fold increase over control in testosterone 2 a hydroxylase -followed by vinclozolin and acephate,coadministration with the former markedly reduced induction.Coadministration with vinclozolin,determined various positive and negative modulations.An increase of CYP2B1/2 and CYP3A1/2-associated oxidases and a decrease of ethoxycoumarin metabolism was observed in the acephate and vinclozolin mixture. An equivalent or reduced CYP expression,if compared to double combinations,was seen using the complete mixture.Taken as a whole, the unpredictability of the recorded e ?ects with simple mixtures,shrinks the misleading extrapolation performed on a single pesticide.If reproduced in human,such changes,altering either endogenous metabolism or biotransformation of ubiquitous toxins,might have public health implications. (literal)

Prodotto di

• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)
• Institute of clinical physiology (IFC) (Istituto)

Insieme di parole chiave

• Parole chiave di "Perturbation of murine liver cyp-superfamily of isoforms by di different combinations of pesticide mixtures" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of clinical physiology (IFC) (Istituto)
• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Food and chemical toxicology (Rivista)

Insieme di parole chiave di

• Parole chiave di "Perturbation of murine liver cyp-superfamily of isoforms by di different combinations of pesticide mixtures" (Insieme di parole chiave)