Circulating levels of lectin-like oxidized low-density lipoprotein receptor-1 are associated with inflammatory markers (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Circulating levels of lectin-like oxidized low-density lipoprotein receptor-1 are associated with inflammatory markers (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s11745-008-3227-9 (literal)

Alternative label

• Lubrano V.; Del Turco S.; Nicolini G.; Di Cecco P.; Basta G. (2008)
  Circulating levels of lectin-like oxidized low-density lipoprotein receptor-1 are associated with inflammatory markers
  in Lipids
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Lubrano V.; Del Turco S.; Nicolini G.; Di Cecco P.; Basta G. (literal)

Pagina inizio

• 945 (literal)

Pagina fine

• 950 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 43 (literal)

Rivista

• Lipids (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: Lipids, vol. 43 (10) pp. 945 - 950. Springer, 2008. (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)
• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Fisiologia Clinica CNR, Pisa Fondazione G. Monasterio Pisa, Pisa (literal)

Titolo

• Circulating levels of lectin-like oxidized low-density lipoprotein receptor-1 are associated with inflammatory markers (literal)

Abstract

• Lectin-like oxidized-low-density lipoprotein receptor-1 (LOX-1) is increasingly linked to atherosclerotic plaque formation and the soluble form of this receptor may reflect activities of disease. We investigated the associations among levels of sLOX-1, oxidized-low-density lipoprotein (ox-LDL), cytokines and the extension of atherosclerosis in patients with coronary artery disease (CAD). Lipid, TNF-a, IL-6, C reactive protein (CRP), ox-LDL, peroxy radical and sLOX-1 levels were measured in 29 controls and 60 patients with CAD, 30 of which with one or two vessels involved (group 1), and 30 patients with three or four vessels involved (group 2). The serum levels of sLOX-1 were significantly and progressively higher in group 1 [611 (346-1,313) pg/ml, median (interquartile range)] and in group 2 [2,143 (824-3,201) pg/ml] than in control subjects [268 (111-767) pg/ml]. LOX-1 levels positively correlated with IL-6 ( r = 0.38, P = 0.0042), TNF- a ( r = 0.38, P = 0.0037), CRP levels ( r = 0.32, P = 0.027) and age ( r = 0.25, P = 0.048). In the multivariate analysis TNF-a resulted the only independent determinant of LOX-1 serum levels (ß-value = 0.304, P = 0.017). These findings suggest that sLOX-1 levels are up-regulated during CAD progression and are associated with inflammatory markers. The measurement of the circulating soluble form of this receptor may be potentially useful in predicting CAD progression in humans. (literal)

Prodotto di

• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• SERENA DEL TURCO (Persona)
• GIUSEPPINA BASTA (Persona)
• GIUSEPPINA NICOLINI (Persona)
• PIETRO DI CECCO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Circulating levels of lectin-like oxidized low-density lipoprotein receptor-1 are associated with inflammatory markers" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• MEDICINA TRASLAZIONALE (ME.P05.016.001) (Modulo)

Autore CNR di

• GIUSEPPINA BASTA (Persona)
• PIETRO DI CECCO (Unità di personale interno)
• GIUSEPPINA NICOLINI (Persona)
• SERENA DEL TURCO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Lipids (Rivista)

Insieme di parole chiave di

• Keywords of "Circulating levels of lectin-like oxidized low-density lipoprotein receptor-1 are associated with inflammatory markers" (Insieme di parole chiave)