Acute effects of triiodothyronine replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Acute effects of triiodothyronine replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study (Articolo in rivista) (literal)

Anno

• 2008-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1210/jc.2007-2210 (literal)

Alternative label

• Pingitore A.; Galli E.; Barison A.; Iervasi A.; Scarlattini M.; Nucci D.; L'Abbate A.; Mariotti R.; Iervasi G. (2008)
  Acute effects of triiodothyronine replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study
  in The Journal of clinical endocrinology and metabolism
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pingitore A.; Galli E.; Barison A.; Iervasi A.; Scarlattini M.; Nucci D.; L'Abbate A.; Mariotti R.; Iervasi G. (literal)

Pagina inizio

• 1351 (literal)

Pagina fine

• 1358 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 93 (literal)

Rivista

• ?The ?Journal of clinical endocrinology and metabolism (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note

• In: Journal of Clinical Endocrinology and Metabolism, vol. 93 pp. 1351 - 1358. jcem.endojournals.org, 2008. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IFC-CNR, Pisa, Scuola Superiore S. Anna Pisa, Dipartimento Cardiotoracico - Università di Pisa (literal)

Titolo

• Acute effects of triiodothyronine replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study (literal)

Abstract

• Context. Low-Triiodothyronine (T3) syndrome is a predictor of poor outcome in patients with cardiac dysfunction. The study aimed to assess the short-term effects of synthetic L-T3 replacement therapy in patients with low-T3 syndrome and ischemic or non-ischemic dilated cardiomyopathy (DC). Design. Twenty clinically stable patients with ischemic (n=12) or non-ischemic (n=8) DC were enrolled. Ten patients (average age 72, range 66-77 years; median, 25-75 percentile) underwent 3-day synthetic L-T3 infusion (study group); the other 10 patients (average age 68, range 64-71 years) underwent placebo infusion (control group). Clinical examination, electrocardiography, cardiac magnetic resonance and bio-humoral profile (free thyroid hormones, thyrotropin [TSH], plasma renin activity, aldosterone, noradrenaline, N-Terminal-pronatriuretic peptide [NT-proBNP] and interleukin-6) were assessed at baseline and after 3-day synthetic L-T3 (initial dose: 20 mg/m2 body surface/day) or placebo infusion. Results. After T3 administration, free T3 concentrations increased until reaching a plateau at 24-48 h (3.43, 3.20-3.84 vs 1.74, 1.62-1.93 pg/ml, p=0.03) without side effects. Heart rate decreased significantly after T3 infusion (63; 60-66 vs 69, 60-76 bpm, p=0.008). Plasma noradrenaline (347; 270-740 vs 717, 413-808 pg/ml, p=0.009), NT-proBNP (3000, 438-4005 vs 3940, 528-5628 pg/ml, p=0.02) and aldosterone (175, 152-229 vs 231, 154-324 pg/ml, p=0.047) significantly decreased after T3 administration. Neurohormonal profile did not change after placebo infusion in the control group. After synthetic L-T3 administration, left-ventricular end-diastolic volume (142, 132-161 vs 133, 114-158 ml/m2 body surface, p=0.02) and stroke volume (40, 34-44 vs 35, 28-39 ml/m2 body surface, p=0.01) increased, while external and intracardiac workload did not change. Conclusions. In DC patients short-term synthetic L-T3 replacement therapy significantly improved neuroendocrine profile and ventricular performance. These data encourage further controlled trials with more patients and longer periods of synthetic L-T3 administration. (literal)

Prodotto di

• FISIOPATOLOGIA CARDIOPOLMONARE E METABOLICA (ME.P01.011.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• ANNALISA IERVASI (Unità di personale interno)
• MARIA SCARLATTINI (Unità di personale interno)
• GIORGIO IERVASI (Unità di personale interno)
• ALESSANDRO PINGITORE (Persona)

Insieme di parole chiave

• Parole chiave di "Acute effects of triiodothyronine replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ALESSANDRO PINGITORE (Persona)
• GIORGIO IERVASI (Unità di personale interno)
• ANNALISA IERVASI (Unità di personale interno)
• MARIA SCARLATTINI (Unità di personale interno)

Prodotto

• Istituto di fisiologia clinica (IFC) (Istituto)
• FISIOPATOLOGIA CARDIOPOLMONARE E METABOLICA (ME.P01.011.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• ?The ?Journal of clinical endocrinology and metabolism (Rivista)

Insieme di parole chiave di

• Parole chiave di "Acute effects of triiodothyronine replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study" (Insieme di parole chiave)