Mismatch between uniform increase in cardiac glucose uptake and regional contractile dysfunction in pacing-induced heart failure (Articolo in rivista)

Type
Label
  • Mismatch between uniform increase in cardiac glucose uptake and regional contractile dysfunction in pacing-induced heart failure (Articolo in rivista) (literal)
Anno
  • 2007-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1152/ajpheart.00592.2007 (literal)
Alternative label
  • Lionetti V.; Guiducci L.; Simioniuc A.; Aquaro G. D.; Simi C.; De Marchi D.; Burchielli S.; Pratali L.; Piacenti M.; Lombardi M.; Salvadori P.; Pingitore A.; Neglia D.; Recchia F. A. (2007)
    Mismatch between uniform increase in cardiac glucose uptake and regional contractile dysfunction in pacing-induced heart failure
    in American journal of physiology. Heart and circulatory physiology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Lionetti V.; Guiducci L.; Simioniuc A.; Aquaro G. D.; Simi C.; De Marchi D.; Burchielli S.; Pratali L.; Piacenti M.; Lombardi M.; Salvadori P.; Pingitore A.; Neglia D.; Recchia F. A. (literal)
Pagina inizio
  • H2747 (literal)
Pagina fine
  • H2756 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 293 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: American Journal of Physiology-Heart and Circulatory Physiology, vol. 293 (5) pp. H2747 - H2756. American Physiological Society, 2007. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Sector of Medicine, Scuola Superiore Sant'Anna, Pisa; 2Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy; and 3Department of Physiology, New York Medical College, Valhalla, New York (literal)
Titolo
  • Mismatch between uniform increase in cardiac glucose uptake and regional contractile dysfunction in pacing-induced heart failure (literal)
Abstract
  • Increased glucose utilization and regional differences in contractile function are well-known alterations of the failing heart and play an important pathophysiological role. We tested whether, similar to functional derangement, changes in glucose uptake develop following a regional pattern. Heart failure was induced in 13 chronically instrumented minipigs by pacing the left ventricular (LV) free wall at 180 beats/min for 3 wk. Regional changes in contractile function and stress were assessed by magnetic resonance imaging, whereas regional flow and glucose uptake were measured by positron emission tomography utilizing, respectively, the radiotracers [(13)N]ammonia and (18)F-deoxyglucose. In heart failure, LV end-diastolic pressure was 20 +/- 4 mmHg, and ejection fraction was 35 +/- 4% (all P 0.05 vs. control). Sustained pacing-induced dyssynchronous LV activation caused a more pronounced decrease in LV systolic thickening (7.45 +/- 3.42 vs. 30.62 +/- 8.73%, P 0.05) and circumferential shortening (-4.62 +/- 1.0 vs. -7.33 +/- 1.2%, P 0.05) in the anterior/anterior-lateral region (pacing site) compared with the inferoseptal region (opposite site). Conversely, flow was reduced significantly by approximately 32% compared with control and was lower in the opposite site region. Despite these nonhomogeneous alterations, regional end-systolic wall stress was uniformly increased by 60% in the failing LV. Similar to wall stress, glucose uptake markedly increased vs. control (0.24 +/- 0.004 vs. 0.07 +/- 0.01 micromol x min(-1) x g(-1), P 0.05), with no significant regional differences. In conclusion, high-frequency pacing of the LV free wall causes a dyssynchronous pattern of contraction that leads to progressive cardiac failure with a marked mismatch between increased glucose uptake and regional contractile dysfunction. (literal)
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