Bioreactor transient exposure activates specific neurotrophic pathways in cortical neurons. (Articolo in rivista)

Type
Label
  • Bioreactor transient exposure activates specific neurotrophic pathways in cortical neurons. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s12217-008-9102-8 (literal)
Alternative label
  • V. Zimmitti, E. Benedetti, V. Caracciolo, P. Sebastiani, S. Di Loreto. (2010)
    Bioreactor transient exposure activates specific neurotrophic pathways in cortical neurons.
    in Microgravity Science and Technology; Springer, London (Regno Unito)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • V. Zimmitti, E. Benedetti, V. Caracciolo, P. Sebastiani, S. Di Loreto. (literal)
Pagina inizio
  • 37 (literal)
Pagina fine
  • 43 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 22 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IFT-CNR Università degli studi L'Aquila, Sbarro University Phyladelfia USA (literal)
Titolo
  • Bioreactor transient exposure activates specific neurotrophic pathways in cortical neurons. (literal)
Abstract
  • Altered gravity forces might influence neuroplasticity and can provoke changes in biochemical mechanisms. In this contest, neurotrophins have a pivotal role, particularly nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF). A suspension of dissociated cortical cells from rat embryos was exposed to 24 h of microgravity before plating in normal adherent culture system. Expression and transductional signalling pathways of NGF and BDNF were assessed at the end of maturational process (8-10 days in vitro). Rotating wall vessel bioreactor (RWV) preexposition did not induce changes in NGF expression and its high affinity receptor TrkA. On the contrary both BDNF expression and its high affinity receptor TrkB were strongly up-regulated, inducing Erk- 5, but not Erk-1/2 activation and, in turn, MEF2C over-expression and activation. According to our previous and present results, we postulate that relatively short microgravitational stimuli, applied to neural cells during the developmental stage, exert a long time activation of specific neurotrophic pathways. (literal)
Editore
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Editore di
Insieme di parole chiave di
data.CNR.it