Estrogen therapy effects on different vasoactive factors in recent postmenopausal healthy women (Articolo in rivista)

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Label
  • Estrogen therapy effects on different vasoactive factors in recent postmenopausal healthy women (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Maffei S.; Mercuri A.; Zucchelli G. C.; Vassalle C. (2006)
    Estrogen therapy effects on different vasoactive factors in recent postmenopausal healthy women
    in International journal of cardiology (print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Maffei S.; Mercuri A.; Zucchelli G. C.; Vassalle C. (literal)
Pagina inizio
  • 194 (literal)
Pagina fine
  • 199 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 107 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: International Journal of Cardiology, vol. 107 pp. 194-199. Elsevier, 2006. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Estrogen therapy effects on different vasoactive factors in recent postmenopausal healthy women (literal)
Abstract
  • BACKGROUND: To evaluate whether the route of estrogen therapy (ET) may affect the levels of different vasoactive factors in healthy recent post-menopausal women. METHODS: We conducted a cross-over study in 20 healthy nonsmoking women in recent postmenopause (1.8+/-0.1 years). Women received either 1-month oral-ET (O-ET, 2 mg oral micronized 17beta estradiol daily) or transdermal-ET regimen (T-ET, 17beta estradiol 1.5 mg gel daily) with a 1-month wash-out interval. Blood pressure, plasma levels of endothelin-1 (ET), 6-ketoPGF1a (6-ketoPG, prostacyclin metabolite), nitrite/nitrate (NOx), epinephrine (E) and norepinephrine (NE) and lipid profile were measured at baseline and after each treatment. RESULTS: Both regimens significantly reduced E (p0.01) and NE levels (p0.05). O-ET reduced low-density lipoproteins (LDL) levels (p0.05) and increased NOx values (p0.01). Neither regimen caused significant changes of ET or 6-ketoPG. CONCLUSIONS: Our results, obtained in healthy women in recent menopause, indicate that the ratio between vasodilator (NOx and prostacyclin) and vasoconstrictor (ET) bioavailability shifted towards the previous ones after O-ET, while it remained unchanged after T-ET; moreover, catecholamines levels were reduced by both treatments already from 1 month of therapy. These changes might represent very early beneficial effects evoked by ET on the cardiovascular system. (literal)
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