Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in hyperhomocysteinemia (Articolo in rivista)

Type
Label
  • Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in hyperhomocysteinemia (Articolo in rivista) (literal)
Anno
  • 2006-01-01T00:00:00+01:00 (literal)
Alternative label
  • Caruso R.; Campolo J.; Sedda V.; De Chiara B.; Della Noce C.; Baudo F.; Tonini A.; Parolini M.; Cighetti G.; Parodi O. (2006)
    Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in hyperhomocysteinemia
    in Journal of cardiovascular pharmacology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Caruso R.; Campolo J.; Sedda V.; De Chiara B.; Della Noce C.; Baudo F.; Tonini A.; Parolini M.; Cighetti G.; Parodi O. (literal)
Pagina inizio
  • 549 (literal)
Pagina fine
  • 555 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 47 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#note
  • In: Journal of Cardiovascular Pharmacology, vol. 47 pp. 549-555. Lippincott Williams & Wilkins, 2006. (literal)
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Effect of homocysteine lowering by 5-methyltetrahydrofolate on redox status in hyperhomocysteinemia (literal)
Abstract
  • The endothelial dysfunction induced by hyperhomocysteinemia can be reversed by 5-methyltetrahydrofolate(5-MTHF) via homocysteine(Hcy)lowering. An additive antioxidant action of 5-MTHF has been suggested to ameliorate endothelial dysfunction through increased nitric oxide production and superoxide radical scavenging, independent of Hcy lowering. The aim of the study was to assess whether 5-MTHFaffects the redox state in hyperhomocysteinemia. We examined the effect of 3 months of oral 5-MTHF treatment (15 mg/day) on the redox pattern in 48 hyperhomocysteinemic subjects compared to 24 untreated hyperhomocysteinemic subjects. By analysis of variance with repeated measures in the 72 subjects,5-MTHF markedly decreased plasma total Hcy (p-tHcy; P=0.0001) and blood-total glutathione (GSH; b-tGSH; P=0.002). By multivariate linear regression in the treated subjects, p-tHcy changes from baseline to 3 months(adjusted by baseline p-tHcy levels) correlated only with changes in reduced cysteinylglycine (P=0.001). The effects of treatment on Hcy lowering and GSH metabolism were greater in medium than in moderate hyperhomocysteinemia. In conclusion, high-dose 5-MTHF treatment for 3 months ensures marked Hcy lowering to normal values even in subjects with high Hcy levels, and should be the treatment of choice in medium hyperhomocysteinemia. Furthermore, 5-MTHF shows a favorable interaction with GSH metabolism. (literal)
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