The additive prognostic value of restrictive pattern and dipyridamole-induced contractile reserve in idiopathic dilated cardiomyopathy (Articolo in rivista)

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  • The additive prognostic value of restrictive pattern and dipyridamole-induced contractile reserve in idiopathic dilated cardiomyopathy (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.ejheart.2004.10.010 (literal)
Alternative label
  • Pratali L.; Otalsevic P.; Rigo F.; Gherardi S.; Neskovic A.; Picano E. (2005)
    The additive prognostic value of restrictive pattern and dipyridamole-induced contractile reserve in idiopathic dilated cardiomyopathy
    in European journal of heart failure; ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, AMSTERDAM (Paesi Bassi)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pratali L.; Otalsevic P.; Rigo F.; Gherardi S.; Neskovic A.; Picano E. (literal)
Pagina inizio
  • 844 (literal)
Pagina fine
  • 851 (literal)
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  • http://eurjhf.oxfordjournals.org/content/7/5/844.long (literal)
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  • 7 (literal)
Rivista
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  • In: \"Eur Heart Fail\",7 2005,5,844-851 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Clinical Physiology, CNR, Pisa, Italy Cardiovascular Institute Dediije and Belgrade University Medical School, Belgrade, Yugoslavia Cardiology Division, Umberto I Hospital, Mestre, Italy Cardiology Division, Bufalini Hospital, Cesena, Italy (literal)
Titolo
  • The additive prognostic value of restrictive pattern and dipyridamole-induced contractile reserve in idiopathic dilated cardiomyopathy (literal)
Abstract
  • Background: Diastolic dysfunction and lack of contractile reserve are unfavorable prognostic predictors in patients with dilated cardiomyopathy (DCM). Aims: This study aims to assess whether diastolic dysfunction and lack of dipyridamole-induced contractile reserve were additive predictors of poor outcome in patients with DCM. Methods: A total of 116 patients with DCM and ejection fraction (EFb35%) were studied by dipyridamole echo (0.84 mg/kg over 10 min). At rest, a restrictive filling pattern was defined as: E/A ratio N2 and an E-wave deceleration time of b140 ms on transmitral flow velocity profile. Results: Rest wall motion score index (WMSI) was 2.2F0.3 and decreased to 1.9F0.41 after dipyridamole ( pb0.001). During follow-up (median 26.5 months), 22 cardiac deaths occurred. At multivariate analysis, dipyridamole-induced contractile reserve yielded significant incremental prognostic value (RR=0.275, pb0.006) over NYHA class (RR=1.971, pb0.03), angiotensin-converting enzyme inhibitor therapy (RR=0.173, pb0.001), and left ventricular end-diastolic diameter (RR=1.131, pb0.001). The worst prognostic combination was the presence of restrictive pattern at rest and the absence of contractile reserve (DWMSIb0.15). Conclusion: In patients with DCM, the ominous combination of restrictive transmitral flow pattern and lack of contractile reserve during dipyridamole stress predicts an unfavourable outcome. (literal)
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