Induction of tolerance to minor histocompatibility antigens by synthetic peptides (Articolo in rivista)

Type
Label
  • Induction of tolerance to minor histocompatibility antigens by synthetic peptides (Articolo in rivista) (literal)
Anno
  • 2001-01-01T00:00:00+01:00 (literal)
Alternative label
  • Salerno, A., Sireci, G., Dieli, F., Di Sano, C., Caccamo, N. (2001)
    Induction of tolerance to minor histocompatibility antigens by synthetic peptides
    in European journal of immunogenetics (Print)
    (literal)
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  • Salerno, A., Sireci, G., Dieli, F., Di Sano, C., Caccamo, N. (literal)
Pagina inizio
  • 205 (literal)
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  • 28 (literal)
Rivista
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  • 2 (literal)
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  • Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Italy ISMEDA, C.N.R, Palermo, Italy (literal)
Titolo
  • Induction of tolerance to minor histocompatibility antigens by synthetic peptides (literal)
Abstract
  • Background. H-Y is a transplantation antigen that has provided a useful tool for exploring graft rejection in responses to minor histocompatibility antigens encoded by genes on the Y chromosome. Recently, two mouse Y chromosome genes, Uty and Smcy have been characterized. Sequence screening for the presence of allele-specific MHC class I binding motifs identified two peptides, WI and KL, with Db binding motifs. Materials and methods. We have analyzed the immune response induced by in vivo immunization with H-Y peptides administered subcutaneously in adjuvant or in soluble form. Results. Subcutaneous injection of H-Y peptides in IFA induces CD8 T cells displaying cytotoxic and IFN-? activities. Conversely, the continuous delivery of soluble H-Y peptides by mini-osmotic pumps causes inhibition of antigen-specific cytotoxic activity and IFN-? production, but primes regulatory CD8 T cells which suppress both in vivo and in vitro the response of CD8 effector T cells specific for a different H-Y peptide However, this requires that both peptides are present on the same antigen presenting cells, thus indicating that regulatory cells exert linked suppression. Conclusions. The efficacy of a single peptide to tolerize CD8+ T lymphocytes might be relevant to design peptide-based therapies to downregulate CTL activity in transplant immunology. (literal)
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