Sequestration of T lymphocytes to body fluids in tuberculosis: reversal of anergy following chemotherapy. (Articolo in rivista)

Type
Label
  • Sequestration of T lymphocytes to body fluids in tuberculosis: reversal of anergy following chemotherapy. (Articolo in rivista) (literal)
Anno
  • 1999-01-01T00:00:00+01:00 (literal)
Alternative label
  • Dieli F, Friscia G, Di Sano C, Ivanyi J, Singh M, Spallek R, Sireci G, Titone L, Salerno A. (1999)
    Sequestration of T lymphocytes to body fluids in tuberculosis: reversal of anergy following chemotherapy.
    in The Journal of infectious diseases
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Dieli F, Friscia G, Di Sano C, Ivanyi J, Singh M, Spallek R, Sireci G, Titone L, Salerno A. (literal)
Pagina inizio
  • 225 (literal)
Pagina fine
  • 228 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 180 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 1 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of General Pathology Division of Infectious Diseases, University of Palermo Immunopathology Section, Institute for Advanced Diagnostic Methodologies, National Research Council, Palermo, Italy MRC Tuberculosis and Related Infections Unit, Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom Gesellschaft fur Biotechnologische Forschung, Braunschweig, Germany (literal)
Titolo
  • Sequestration of T lymphocytes to body fluids in tuberculosis: reversal of anergy following chemotherapy. (literal)
Abstract
  • The specificity of CD4 T lymphocytes was investigated in 6 patients affected by tuberculosis who had negative tuberculin purified protein derivative (PPD) skin tests at diagnosis. Polyclonal CD4 T cell lines from the peripheral blood failed to proliferate to PPD and to the 16- or 38-kDa proteins of Mycobacterium tuberculosis, while CD4 cell lines from the disease site responded to PPD and to the 16- and 38-kDa proteins and derived epitopes in vitro. Four months after chemotherapy, the patients became responsive to PPD. The proliferative response to PPD and to the 16- or 38-kDa proteins and their derived peptides decreased in CD4 T cell lines from the disease site and increased in lines from the peripheral blood. These results indicate that CD4 T cells recognizing a vast array of M. tuberculosis epitopes are compartmentalized at the site of disease in anergic patients but appear in peripheral blood after chemotherapy. (literal)
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