Broad clonal heterogeneity of antigen-specific CD4+ T-cells localizing at the site of disease during tuberculosis. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Broad clonal heterogeneity of antigen-specific CD4+ T-cells localizing at the site of disease during tuberculosis. (Articolo in rivista) (literal)

Anno

• 1999-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0165-2478(99)00107-8 (literal)

Alternative label

• Dieli F, Sireci G, Ivanyi J, Singh M, Friscia G, Di Sano C, Spallek R, Salerno A. (1999)
  Broad clonal heterogeneity of antigen-specific CD4+ T-cells localizing at the site of disease during tuberculosis.
  in Immunology letters
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Dieli F, Sireci G, Ivanyi J, Singh M, Friscia G, Di Sano C, Spallek R, Salerno A. (literal)

Pagina inizio

• 311 (literal)

Pagina fine

• 315 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 69 (literal)

Rivista

• Immunology letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of General Pathology, University of Palermo, 90134 Palermo, Italy MRC Tuberculosis and Related Infections Unit, Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 0NN, UK Gesellschaft fur Biotechnologische Forschung, Mascheroder Weg 1, D-38124 Braunschweig, Germany Immunopathology Section, Institute for Advanced Diagnostic Methodologies, National Research Council, 90134 Palermo, Italy (literal)

Titolo

• Broad clonal heterogeneity of antigen-specific CD4+ T-cells localizing at the site of disease during tuberculosis. (literal)

Abstract

• The repertoire of CD4+ T-lymphocytes was investigated in six patients affected by tuberculosis, who had a negative PPD skin test at diagnosis. Polyclonal CD4+ T-cell lines from the peripheral blood failed to proliferate to PPD and to the 16- or 38-kDa proteins of Mycobacterium tuberculosis, while CD4+ T-cell lines from the site of disease responded to PPD, and to the 16- and 38-kDa proteins, and derived epitopes in vitro. The repertoire of CD4+ T-cells accumulating at the site of disease was found to be widely heterogeneous as demonstrated by the finding that at least seven different peptides from the 16- and 38-kDa proteins were recognized by every patient. These results indicate that CD4+ T-cells localized at the site of disease in tuberculosis recognize a vast array of M. tuberculosis epitopes. (literal)

Prodotto di

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Immunoregolazione TBC e Trapianti (ME.P04.003.001) (Modulo)

Autore CNR

• FRANCESCO DIELI (Unità di personale esterno)
• CATERINA DI SANO (Unità di personale interno)
• ALFREDO SALERNO (Unità di personale esterno)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Immunoregolazione TBC e Trapianti (ME.P04.003.001) (Modulo)

Autore CNR di

• CATERINA DI SANO (Unità di personale interno)
• FRANCESCO DIELI (Unità di personale esterno)
• ALFREDO SALERNO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Immunology letters (Rivista)