Change of Th0 to Th1 cell-cytokine profile following tuberculosis chemotherapy. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Change of Th0 to Th1 cell-cytokine profile following tuberculosis chemotherapy. (Articolo in rivista) (literal)

Anno

• 2000-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1046/j.1365-3083.2000.00744.x (literal)

Alternative label

• Dieli F, Singh M, Spallek R, Romano A, Titone L, Sireci G, Friscia G, Di Sano C, Santini D, Salerno A, Ivanyi J. (2000)
  Change of Th0 to Th1 cell-cytokine profile following tuberculosis chemotherapy.
  in Scandinavian journal of immunology (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Dieli F, Singh M, Spallek R, Romano A, Titone L, Sireci G, Friscia G, Di Sano C, Santini D, Salerno A, Ivanyi J. (literal)

Pagina inizio

• 96 (literal)

Pagina fine

• 102 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 52 (literal)

Rivista

• Scandinavian journal of immunology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Section of Pathology, Department of Biopathology, University of Palermo, 90134 Palermo, Italy, Gesellschaft für Biotechnologische Forschung, Mascheroder Weg 1, D-38124 Braunschweig, Germany, Division of Infectious Diseases, University of Palermo, 90134 Palermo, Italy, University 'Campus Biomedico', Rome, Italy, Institute of Advanced Diagnostic Methodologies, National Research Council, 90134 Palermo, Italy, Department of Oral Medicine & Pathology, KCL Medical & Dental School at Guy's Hospital, London SE1 9RT, UK (literal)

Titolo

• Change of Th0 to Th1 cell-cytokine profile following tuberculosis chemotherapy. (literal)

Abstract

• T cells mediate protection against tuberculosis, but little is known about their role during chemotherapy of patients with active disease. Here we examined the cytokine profile of CD4 T cells before and after four months of chemotherapy in six initial skin test anergic cases. Purified protein derivative (PPD) and 16-kDa antigen-reactive CD4 T-cell clones prior to therapy resided mostly in disease-associated body fluids and were of the Th0 (interferon (IFN)-gamma + interleukin (IL)-4) secreting profile. In contrast, the majority of postchemotherapy CD4 T-cell clones originated from blood and were of the IFN-gamma secreting Th1 type. However, the recognition of several peptides derived from the 16-kDa antigen was not significantly different between the Th1 and Th0 clones. We conclude that chemotherapy shifts CD4 T cells from the affected body fluids to the blood circulation, accompanied by a change from Th0 to Th1 cytokine profile. (literal)

Prodotto di

• Immunoregolazione TBC e Trapianti (ME.P04.003.001) (Modulo)
• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)

Autore CNR

• ALFREDO SALERNO (Unità di personale esterno)
• FRANCESCO DIELI (Unità di personale esterno)
• CATERINA DI SANO (Unità di personale interno)

Incoming links:

Prodotto

• Istituto di biomedicina e di immunologia molecolare \"Alberto Monroy\" (IBIM) (Istituto)
• Immunoregolazione TBC e Trapianti (ME.P04.003.001) (Modulo)

Autore CNR di

• CATERINA DI SANO (Unità di personale interno)
• FRANCESCO DIELI (Unità di personale esterno)
• ALFREDO SALERNO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Scandinavian journal of immunology (Rivista)