http://www.cnr.it/ontology/cnr/individuo/prodotto/ID236949
Whole body irradiation induces IFN-gamma production in BALB/c mice by preventing the appearance of a V alpha 14(+)NK T downregulatory population. (Articolo in rivista)
- Type
- Label
- Whole body irradiation induces IFN-gamma production in BALB/c mice by preventing the appearance of a V alpha 14(+)NK T downregulatory population. (Articolo in rivista) (literal)
- Anno
- 2000-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1006/cyto.2000.0709 (literal)
- Alternative label
Dieli F, Taniguchi M, Asherson GL, Sireci G, Di Sano C, Cigna D, Salerno A. (2000)
Whole body irradiation induces IFN-gamma production in BALB/c mice by preventing the appearance of a V alpha 14(+)NK T downregulatory population.
in Cytokine (Online)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Dieli F, Taniguchi M, Asherson GL, Sireci G, Di Sano C, Cigna D, Salerno A. (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
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- Section of Pathology, Department of Biopathology, University of Palermo, 90134, Palermo, Italy
Division of Molecular Immunology, Center for Biomedical Sciences, Chiba University, Chiba, 260, Japan
Twentieth Century History of Medicine, Wellcome Institute for the History of Medicine, London, NW1 2BE, UK
Immunopathology Section, ISMEDA-CNR, 90134, Palermo, Italy (literal)
- Titolo
- Whole body irradiation induces IFN-gamma production in BALB/c mice by preventing the appearance of a V alpha 14(+)NK T downregulatory population. (literal)
- Abstract
- Lymph node cells from TNCB-immune BALB/c mice fail to produce IFN-? when exposed to antigen in vitro. Conversely, lymph node cells of irradiated (550 rads) BALB/c mice produce IFN-?. Transfer experiments show that normal BALB/c mice contain cells which suppress IFN-? production. These downregulatory cells are CD4+??+and rearrange the invariant V?14-J?281 T cell receptor ? chain, thus belonging to the NK T cell subset. Downregulatory cells probably act by producing IL-4 as their effect is blocked by mAb to IL-4. (literal)
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