Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II. (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/srep02070 (literal)

Alternative label

• Barbara Salani 1,2; Cecilia Marini 3; Alberto Del Rio 4; Silvia Ravera 5; Michela Massollo 2,6; Anna Maria Orengo 2; Adriana Amaro 2; Mario Passalacqua 7; Sara Maffioli 1,2; Ulrich Pfeffer 2; Renzo Cordera 1,2; Davide Maggi 1,2; Gianmario Sambuceti 2,6. (2013)
  Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II.
  in Scientific reports (Nature Publishing Group)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Barbara Salani 1,2; Cecilia Marini 3; Alberto Del Rio 4; Silvia Ravera 5; Michela Massollo 2,6; Anna Maria Orengo 2; Adriana Amaro 2; Mario Passalacqua 7; Sara Maffioli 1,2; Ulrich Pfeffer 2; Renzo Cordera 1,2; Davide Maggi 1,2; Gianmario Sambuceti 2,6. (literal)

Pagina inizio

• 2070 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 3 (literal)

Rivista

• Scientific reports (Rivista)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Department of Internal Medicine (DIMI) University of Genova, Genova, Italy. 2 IRCCS Azienda Ospedaliera Universitaria San Martino- IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy. 3. CNR Institute of Molecular Bioimaging and Physiology (IBFM), Genova section, Genova, Italy. 4. Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum-University of Bologna, Bologna, Italy. 5. Department of Pharmacy (DIFAR), University of Genova, Genova, Italy. 6. Nuclear Medicine, Department of Health Science (DISSAL), University of Genova, Genova, Italy. 7. Department of Experimental Medicine (DIMES), University of Genova, Genova, Italy. (literal)

Titolo

• Metformin Impairs Glucose Consumption and Survival in Calu-1 Cells by Direct Inhibition of Hexokinase-II. (literal)

Abstract

• The anti-hyperglycaemic drug metformin has important anticancer properties as shown by the direct inhibition of cancer cells proliferation. Tumor cells avidly use glucose as a source for energy production and cell building blocks. Critical to this phenotype is the production of glucose-6-phosphate (G6P), catalysed by hexokinases (HK) I and II, whose role in glucose retention and metabolism is highly advantageous for cell survival and proliferation. Here we show that metformin impairs the enzymatic function of HKI and II in Calu-1 cells. This inhibition virtually abolishes cell glucose uptake and phosphorylation as documented by the reduced entrapment of (18)F-fluorodeoxyglucose. In-silico models indicate that this action is due to metformin capability to mimic G6P features by steadily binding its pocket in HKII. The impairment of this energy source results in mitochondrial depolarization and subsequent cell death. These results could represent a starting point to open effective strategies in cancer prevention and treatment. (literal)

Prodotto di

• Attività fisica e risposta cardiocircolatoria nella patologia dismetabolica e cardiovascolare (ME.P01.002.006) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• CECILIA MARINI (Unità di personale interno)

Incoming links:

Autore CNR di

• CECILIA MARINI (Unità di personale interno)

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Attività fisica e risposta cardiocircolatoria nella patologia dismetabolica e cardiovascolare (ME.P01.002.006) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Scientific reports (Rivista)