Inhibition of influenza A virus replication by resveratrol (Articolo in rivista)

Type
Label
  • Inhibition of influenza A virus replication by resveratrol (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1086/429694 (literal)
Alternative label
  • Anna T. Palamara,1 Lucia Nencioni,1 Katia Aquilano,2 Giovanna De Chiara,3 Leyanis Hernandez,3 Federico Cozzolino,4 Maria R. Ciriolo,2 and Enrico Garaci3 (2005)
    Inhibition of influenza A virus replication by resveratrol
    in The Journal of infectious diseases
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Anna T. Palamara,1 Lucia Nencioni,1 Katia Aquilano,2 Giovanna De Chiara,3 Leyanis Hernandez,3 Federico Cozzolino,4 Maria R. Ciriolo,2 and Enrico Garaci3 (literal)
Pagina inizio
  • 1719 (literal)
Pagina fine
  • 1729 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 191 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Institute of Microbiology, University of Rome \"La Sapienza,\" Departments of 2Biology and 3Experimental Medicine and Biochemical Sciences, University of Rome \"Tor Vergata,\" and 4Institute of Neurobiology and Molecular Medicine, Italian National Research Council, Rome, Italy (literal)
Titolo
  • Inhibition of influenza A virus replication by resveratrol (literal)
Abstract
  • We have previously shown that the life cycles of several viruses are influenced by host-cell redox states. Reports of the antioxidant activities of the plant polyphenol resveratrol (RV) prompted us to investigate its effects on influenza virus replication in vitro and in vivo.We found that RV strongly inhibited the replication of influenza virus in MDCK cells but that this activity was not directly related to glutathione-mediated antioxidant activity. Rather, it involved the blockade of the nuclear-cytoplasmic translocation of viral ribonucleoproteins and reduced expression of late viral proteins seemingly related to the inhibition of protein kinase C activity and its dependent pathways. RV also significantly improved survival and decreased pulmonary viral titers in influenza virus-infected mice. No toxic effects were observed in vitro or in vivo. That RV acts by inhibiting a cellular, rather than a viral, function suggests that it could be a particularly valuable anti-influenza drug. (literal)
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