The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data (Articolo in rivista)

Type
Label
  • The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • 32. Middeldorp CM, de Moor MH, McGrath LM, Gordon SD, Blackwood DH, Costa PT, Terracciano A, Krueger RF, de Geus EJ, Nyholt DR, Tanaka T, Esko T, Madden PA, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Ripke S, Sullivan PF, Realo A, Allik J, Heath AC, Pergadia ML, Agrawal A, Lin P, Grucza RA, Widen E, Cousminer DL, Eriksson JG, Palotie A, Barnett JH, Lee PH, Luciano M, Tenesa A, Davies G, Lopez LM, Hansell NK, Medland SE, Ferrucci L, Schlessinger D, Montgomery GW, Wright MJ, Aulchenko YS, Janssens AC, Oostra BA, Metspalu A, Abecasis GR, Deary IJ, Räikkönen K, Bierut LJ, Martin NG, Wray NR, van Duijn CM, Smoller JW, Penninx BW, Boomsma DI (2011)
    The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data
    in Translational psychiatry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • 32. Middeldorp CM, de Moor MH, McGrath LM, Gordon SD, Blackwood DH, Costa PT, Terracciano A, Krueger RF, de Geus EJ, Nyholt DR, Tanaka T, Esko T, Madden PA, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Uda M, Sanna S, Spinhoven P, Hartman CA, Ripke S, Sullivan PF, Realo A, Allik J, Heath AC, Pergadia ML, Agrawal A, Lin P, Grucza RA, Widen E, Cousminer DL, Eriksson JG, Palotie A, Barnett JH, Lee PH, Luciano M, Tenesa A, Davies G, Lopez LM, Hansell NK, Medland SE, Ferrucci L, Schlessinger D, Montgomery GW, Wright MJ, Aulchenko YS, Janssens AC, Oostra BA, Metspalu A, Abecasis GR, Deary IJ, Räikkönen K, Bierut LJ, Martin NG, Wray NR, van Duijn CM, Smoller JW, Penninx BW, Boomsma DI (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands 2Neuroscience Campus Amsterdam, Amsterdam, The Netherlands 3Department of Child and Adolescent Psychiatry, Academic Medical Center, Amsterdam, The Netherlands 4Department of Child and Adolescent Psychiatry, GGZ inGeest/VU Medical Center, Amsterdam, The Netherlands 5Department of Psychiatry and Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA 6Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia 7Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK 8National Institute on Aging, NIH, Baltimore, MD, USA 9Department of Psychology, University of Minnesota, Baltimore, MD, USA 10Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia 11Estonian Biocentre, Tartu, Estonia 12Estonian Genome Center of University of Tartu, Tartu, Estonia 13Department of Psychiatry, Washington University School of Medicine, St Louis, Washington, USA 14Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands 15EMGO Institute for Health And Care Research, VU University Medical Center, Amsterdam, The Netherlands 16Istituto di Neurogenetica e Neurofarmacologia, Cagliari, Italy 17Departments of Clinical Psychology and Psychiatry, Leiden University, Leiden, The Netherlands 18Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands 19Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA 20Department of Genetics, University of North Carolina at Chapel Hill, NC, Chapel Hill, USA 21Department of Psychology, University of Tartu, Tartu, Estonia 22Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland 23National Institute for Health and Welfare, Helsinki, Finland 24Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland 25Vasa Central Hospital, Vasa, Finland 26Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland 27Folkhälsan Research Centre, Helsinki, Finland 28Wellcome Trust Genome Campus, Wellcome Trust Sanger Institute, Cambridge, UK 29Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland 30Department of Psychiatry, University of Cambridge, Cambridge, UK 31Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK 32MRC Human Genetics Unit, The Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK 33Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands 34Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA 35Department of Psychology, University of Helsinki, Helsinki, Finland 36Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands (literal)
Titolo
  • The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data (literal)
Abstract
  • The relationship between major depressive disorder (MDD) and bipolar disorder (BD) remains controversial. Previous research has reported differences and similarities in risk factors for MDD and BD, such as predisposing personality traits. For example, high neuroticism is related to both disorders, whereas openness to experience is specific for BD. This study examined the genetic association between personality and MDD and BD by applying polygenic scores for neuroticism, extraversion, openness to experience, agreeableness and conscientiousness to both disorders. Polygenic scores reflect the weighted sum of multiple single-nucleotide polymorphism alleles associated with the trait for an individual and were based on a meta-analysis of genome-wide association studies for personality traits including 13,835 subjects. Polygenic scores were tested for MDD in the combined Genetic Association Information Network (GAIN-MDD) and MDD2000+ samples (N=8921) and for BD in the combined Systematic Treatment Enhancement Program for Bipolar Disorder and Wellcome Trust Case-Control Consortium samples (N=6329) using logistic regression analyses. At the phenotypic level, personality dimensions were associated with MDD and BD. Polygenic neuroticism scores were significantly positively associated with MDD, whereas polygenic extraversion scores were significantly positively associated with BD. The explained variance of MDD and BD, ~0.1%, was highly comparable to the variance explained by the polygenic personality scores in the corresponding personality traits themselves (between 0.1 and 0.4%). This indicates that the proportions of variance explained in mood disorders are at the upper limit of what could have been expected. This study suggests shared genetic risk factors for neuroticism and MDD on the one hand and for extraversion and BD on the other. (literal)
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