Bayesian models for the analysis of multisample time-course micro-array experiments (Articolo in rivista)

Type
Label
  • Bayesian models for the analysis of multisample time-course micro-array experiments (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/978-3-642-35686-5_3 (literal)
Alternative label
  • C. Angelini, D. De Canditiis, M. Pensky, N. Brownstain (2012)
    Bayesian models for the analysis of multisample time-course micro-array experiments
    in Lecture notes in computer science; Springer, Berlin Heidelberg (Germania)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • C. Angelini, D. De Canditiis, M. Pensky, N. Brownstain (literal)
Pagina inizio
  • 21 (literal)
Pagina fine
  • 35 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://link.springer.com/chapter/10.1007%2F978-3-642-35686-5_3 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 7548 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 15 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto per le Applicazioni del Calcolo CNR, Italy Department of Mathematics, University of Central Florida, USA Department of Biostatistics, University of North Carolina at Chapel Hill, USA (literal)
Titolo
  • Bayesian models for the analysis of multisample time-course micro-array experiments (literal)
Abstract
  • In this paper we present a functional Bayesian method for detecting genes which are temporally differentially expressed between several conditions. We identify the nature of differential expression (e.g., gene is differentially expressed between the first and the second sample but is not differentially expressed between the second and the third) and subsequently we estimate gene expression temporal profiles. The proposed procedure deals successfully with various technical difficulties which arise in microarray time-course experiments such as a small number of observations, non-uniform sampling intervals and presence of missing data or repeated measurements. The procedure allows to account for various types of errors, thus, offering a good compromise between nonparametric and normality assumption based techniques. In addition, all evaluations are carried out using analytic expressions, hence, the entire procedure requires very small computational effort. The performance of the procedure is studied using simulated data. (literal)
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