http://www.cnr.it/ontology/cnr/individuo/prodotto/ID232287

Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity. (Articolo in rivista)

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Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity. (Articolo in rivista) (literal)

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Elisabetta Menna1,2,8, Stefania Zambetti1,3,8, Raffaella Morini2,3, Andrea Donzelli3, Andrea Disanza4, Daniela Calvigioni1,3, Daniela Braida3, Chiara Nicolini5, Marta Orlando3, Giuliana Fossati2,3, Maria Cristina Regondi6, Linda Pattini7, Carolina Frassoni6, Maura Francolini1,3, Giorgio Scita4, Mariaelvina Sala1,3, Margaret Fahnestock5 and Michela Matteoli2,3 (2013)
Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.
in EMBO journal (Print)
(literal)

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Elisabetta Menna1,2,8, Stefania Zambetti1,3,8, Raffaella Morini2,3, Andrea Donzelli3, Andrea Disanza4, Daniela Calvigioni1,3, Daniela Braida3, Chiara Nicolini5, Marta Orlando3, Giuliana Fossati2,3, Maria Cristina Regondi6, Linda Pattini7, Carolina Frassoni6, Maura Francolini1,3, Giorgio Scita4, Mariaelvina Sala1,3, Margaret Fahnestock5 and Michela Matteoli2,3 (literal)

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1CNR Institute of Neuroscience, Milano, Italy 2Humanitas Clinical and Research Center, Milan, Italy 3Department of Medical Biotechnology and Translational Medicine, University of Milano, Milan, Italy 4IFOM Foundation--FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy 5Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada 6Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Clinical Epileptology and Experimental Neurophysiology Unit, Milan, Italy 7Dipartimento di Elettronica, Informazione e Bioingegneria--Politecnico di Milano, Milan, Italy (literal)

Titolo

Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity. (literal)

Abstract

Actin-based remodelling underlies spine structural changes occurring during synaptic plasticity, the process that constantly reshapes the circuitry of the adult brain in response to external stimuli, leading to learning and memory formation. A positive correlation exists between spine shape and synaptic strength and, consistently, abnormalities in spine number and morphology have been described in a number of neurological disorders. In the present study, we demonstrate that the actin-regulating protein, Eps8, is recruited to the spine head during chemically induced long-term potentiation in culture and that inhibition of its actin-capping activity impairs spine enlargement and plasticity. Accordingly, mice lacking Eps8 display immature spines, which are unable to undergo potentiation, and are impaired in cognitive functions. Additionally, we found that reduction in the levels of Eps8 occurs in brains of patients affected by autism compared to controls. Our data reveal the key role of Eps8 actin-capping activity in spine morphogenesis and plasticity and indicate that reductions in actin-capping proteins may characterize forms of intellectual disabilities associated with spine defects. (literal)

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