http://www.cnr.it/ontology/cnr/individuo/prodotto/ID231694

Classical and unconventional pathways of vesicular release in microglia (Articolo in rivista)

Type

Label

Classical and unconventional pathways of vesicular release in microglia (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Ilaria Prada1, Roberto Furlan2, Michela Matteoli1,3, Claudia Verderio3,4,* (2013)
Classical and unconventional pathways of vesicular release in microglia
in GLIA (N.Y.N.Y. : Print)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Ilaria Prada1, Roberto Furlan2, Michela Matteoli1,3, Claudia Verderio3,4,* (literal)

Rivista

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1Humanitas Clinical and Research Center, Rozzano (MI), Italy; 2INSPE, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy; 3Department of Biotechnology and Translational Medicine, University of Milano, Milan, Italy; 4CNR-Institute of Neuroscience, Milan, Italy (literal)

Titolo

Classical and unconventional pathways of vesicular release in microglia (literal)

Abstract

Emerging evidence indicates that activation of microglia, the immune cells of the brain, is strictly associated to both secretion of soluble molecules and release of extracellular membrane vesicles (EMVs) into the pericellular space. Through these processes, microglia heavily influence brain cell functions, either propagating inflammation and causing damage to neurons or playing a supportive, neuroprotective role. In this review, we highlight the emerging concepts related to vesicular mechanisms of secretion operating in microglial cells, with the aim of dissecting how microglia communicate with other cell types within the brain microenvironment in health and disease. (literal)

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