Kinetic and anion inhibition studies of a beta-carbonic anhydrase (FbiCA 1) from the C-4 plant Flaveria bidentis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Kinetic and anion inhibition studies of a beta-carbonic anhydrase (FbiCA 1) from the C-4 plant Flaveria bidentis (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.bmcl.2013.01.087 (literal)

Alternative label

• Monti, SM ; De Simone, G ; Dathan, NA ; Ludwig, M ; Vullo, D ; Scozzafava, A ; Capasso, C ; Supuran, CT (2013)
  Kinetic and anion inhibition studies of a beta-carbonic anhydrase (FbiCA 1) from the C-4 plant Flaveria bidentis
  in Bioorganic & medicinal chemistry letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Monti, SM ; De Simone, G ; Dathan, NA ; Ludwig, M ; Vullo, D ; Scozzafava, A ; Capasso, C ; Supuran, CT (literal)

Pagina inizio

• 1626 (literal)

Pagina fine

• 1630 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Bioorganic & medicinal chemistry letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• CNR, Ist Biostrutture & Bioimmagini, I-80134 Naples, Italy Univ Western Australia, Sch Chem & Biochem M310, Crawley, WA 6009, Australia Univ Florence, Lab Chim Bioinorgan, I-50019 Florence, Italy CNR, Ist Biochim Prote, I-80131 Naples, Italy Univ Florence, NEUROFARBA Dept, Sez Sci Farmaceut, I-50019 Florence, Italy (literal)

Titolo

• Kinetic and anion inhibition studies of a beta-carbonic anhydrase (FbiCA 1) from the C-4 plant Flaveria bidentis (literal)

Abstract

• Several beta-carbonic anhydrases (CAs, EC 4.2.1.1) are present in all land plants examined thus far. Here we report the first detailed biochemical characterization of one such isoform, FbiCA 1, from the C-4 plant Flaveria bidentis, which was cloned, purified and characterized as recombinant protein. FbiCA 1 has an interesting CO2 hydrase catalytic activity (k(cat) of 1.2 x 10(5) and k(cat)/K-m of 7.5 x 10(6) M-1 x s(-1)) and was moderately inhibited by most simple/complex inorganic anions. Potent FbiCA 1 inhibitors were also detected, such as trithiocarbonate, diethyldithiocarbamate, sulfamide, sulfamic acid, phenylboronic acid and phenylarsonic acid (K(I)s in the range of 4-60 mu M). Such inhibitors may be used as tools to better understand the role of various beta-CA isoforms in photosynthesis. (literal)

Prodotto di

• Institute of biostructure and bioimaging (IBB) (Istituto)

Autore CNR

• GIUSEPPINA DE SIMONE (Unità di personale interno)
• SIMONA MARIA MONTI (Unità di personale interno)
• NINA ALAYNE DATHAN (Persona)
• CLEMENTE CAPASSO (Unità di personale interno)

Incoming links:

Autore CNR di

• CLEMENTE CAPASSO (Unità di personale interno)
• GIUSEPPINA DE SIMONE (Unità di personale interno)
• SIMONA MARIA MONTI (Unità di personale interno)
• NINA ALAYNE DATHAN (Persona)

Prodotto

• Institute of biostructure and bioimaging (IBB) (Istituto)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Bioorganic & medicinal chemistry letters (Rivista)