Asymmetric Tc-Nitrido Complexes for Imaging 5HT1A Receptor (Contributo in atti di convegno)

Type
Label
  • Asymmetric Tc-Nitrido Complexes for Imaging 5HT1A Receptor (Contributo in atti di convegno) (literal)
Anno
  • 2002-01-01T00:00:00+01:00 (literal)
Alternative label
  • Bolzati C.; Mahmood A.; Malagò E.; Boschi A.; Uccelli L.; Friebe M.; Jones A.; Duatti A. (2002)
    Asymmetric Tc-Nitrido Complexes for Imaging 5HT1A Receptor
    in Sixth International Symposium on Technetium in Chemistry and Nuclear Medicine, Bressanone (Bz) IT, September 4-7, 2002
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bolzati C.; Mahmood A.; Malagò E.; Boschi A.; Uccelli L.; Friebe M.; Jones A.; Duatti A. (literal)
Pagina inizio
  • 369 (literal)
Pagina fine
  • 374 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://trove.nla.gov.au/work/34064146?versionId=41932183 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#titoloVolume
  • Technetium, rhenium and other metals in chemistry and nuclear medicine, 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#volumeInCollana
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 6 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 : ICIS, Consiglio Nazionale delle Ricerche, Corso Stati Uniti 4, I-35127 Padova, Italy / 2,6,7 : Harvard Medical School and Brigham and Woman's Hospital, Boston, Massachusets 02115, USA / 3-5,8 : Laboratory of Nuclear medicine, Department of Clinical & Experimental Medicine, University of Ferrara, Via L. Borsari, 46, 44100 Ferrara, Italy (literal)
Titolo
  • Asymmetric Tc-Nitrido Complexes for Imaging 5HT1A Receptor (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#isbn
  • 8886281730 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#curatoriVolume
  • Marino Nicolini, Ulderico Mazzi (literal)
Abstract
  • The [TcN(PNP)]2+ metal fragment allows the incorporation of a bioactive molecule into a 99mTc-nitrido complex. Herein we describe the first application of this procedure to a 2-methoxyphenyl piperazine (2-MPP) pharmacophore, wich display preferential affinity for the 5HT1A receptors. An N-derivatized cysteine, namely 2-MPPP-cys-OS, where 2-MPPP is 3-[4-(2-methoxyphenyl)piperazin-1-yl]propionate was synthetized as the pharmacophore containing bifunctional-ligand. The asimmetric Tc(V)-nitrido complexes [99g/99m Tc(N)(PNP)(2-MPPP-cys-OS)] (PNP= PNP3, PNP4), were obtained in hig yields (95%), by simultaneous addition of PNP and 2.MPPP-cys-OS ligands to a solution containing a 99mTc-nitrido precursor. Biological evaluation of the complexes were performed by conducting in vitro 5HT1A receptor-binding assays and in vivo biodistribution studies in rats. (literal)
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